Vipin Raj K, Dhote Pawan S, Vanka Kumar, Ramana Chepuri V
Physical and Materials Chemistry Division, CSIR-National Chemical Laboratory, Pune, India.
Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, India.
Front Chem. 2021 Jul 9;9:689780. doi: 10.3389/fchem.2021.689780. eCollection 2021.
Gold-catalysis, in this century, is one of the most emerging and promising new areas of research in organic synthesis. During the last two decades, a wide range of distinct synthetic methodologies have been unveiled employing homogeneous gold catalysis and aptly applied in the synthesis of numerous natural products and biologically active molecules. Among these, the reactions involving α-oxo gold carbene/α-imino gold carbene intermediates are of contemporary interest, in view of their synthetic potential and also due to the need to understand the bonding involved in these complexes. In this manuscript, we document the theoretical investigations on the regio-selectivity dependence of substitution on the gold-catalyzed cycloisomerization of -nitroarylalkyne derivatives. We have also studied the relative stabilities of α-oxo gold carbene intermediates.
在本世纪，金催化是有机合成中最具新兴性和前景的研究新领域之一。在过去二十年中，已揭示出多种不同的合成方法，这些方法采用均相金催化，并恰当地应用于众多天然产物和生物活性分子的合成。其中，涉及α-氧代金卡宾/α-亚胺基金卡宾中间体的反应因其合成潜力以及理解这些配合物中键合的必要性而备受当代关注。在本手稿中，我们记录了关于取代基的区域选择性对金催化的硝基芳基炔烃衍生物环异构化的影响的理论研究。我们还研究了α-氧代金卡宾中间体的相对稳定性。
