Tavakkoli Mahmood, Aali Saeed, Khaledifar Borzoo, Ferns Gordon A, Khazaei Majid, Fekri Kiavash, Arjmand Mohammad-Hassan
Kidney Transplantation Complications Research Center, Department of Internal Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Department of Urology, Kashani Academic Hospital, Shahrekord University of Medical Sciences, Shahrekord, Iran.
Gastrointest Tumors. 2021 Jun;8(3):107-114. doi: 10.1159/000514614. Epub 2021 Mar 31.
Post-surgical adhesion bands (PSABs) are a common complication after abdominal or pelvic surgeries for different reasons like cancer treatment. Despite improvements in surgical techniques and the administration of drugs or the use of physical barriers, there has only been limited improvement in the frequency of postoperative adhesions. Complications of PSAB are pain, infertility, intestinal obstruction, and increased mortality. The most important molecular mechanisms for the development of PSAB are inflammatory response, oxidative stress, and overexpression of pro-fibrotic molecules such as transforming growth factor β. However, questions remain about the pathogenesis of this problem, for example, the causes for individual differences or why certain tissue sites are more prone to post-surgical adhesions.
Addressing the pathological causes of PSAB, the potential role of local angiotensin II/angiotensin II type 1 receptors (AngII/AT1R), may help to prevent this problem.
The objective of this article was to explore the role of the AngII/AT1R axis potential to induce PSAB and the therapeutic potential of angiotensin receptor blockers in the prevention and treatment of PSAB.
术后粘连带（PSABs）是腹部或盆腔手术后常见的并发症，其病因多样，如癌症治疗。尽管手术技术有所改进，药物应用或物理屏障的使用也有所增加，但术后粘连的发生率仅得到有限改善。PSAB的并发症包括疼痛、不孕、肠梗阻和死亡率增加。PSAB形成的最重要分子机制是炎症反应、氧化应激以及促纤维化分子如转化生长因子β的过度表达。然而，关于这个问题的发病机制仍存在疑问，例如个体差异的原因或为何某些组织部位更容易发生术后粘连。
针对PSAB的病理原因，局部血管紧张素II/血管紧张素II 1型受体（AngII/AT1R）的潜在作用可能有助于预防这一问题。
本文的目的是探讨AngII/AT1R轴在诱导PSAB中的作用以及血管紧张素受体阻滞剂在预防和治疗PSAB方面的治疗潜力。
