Li Min, Wu Junru, Ma Wenbo, Zhang Zhihao, Zhang Mingsha, Li Xuemei, Ling Zhipei, Xu Xin
State Key Laboratory of Cognitive Neuroscience and Learning and IDG/McGovern Institute for Brain Research, Division of Psychology, Beijing Normal University, Beijing 100875, China.
Cadre Medical Department, the 1st Clinical Center, General Hospital of PLA, 28 Fu-Xing Road, Haidian District, Beijing 100853, China.
iScience. 2021 Jun 24;24(7):102764. doi: 10.1016/j.isci.2021.102764. eCollection 2021 Jul 23.
Saccadic eye movements may not stop steadily but fluctuate briefly, known as saccadic dynamic overshoot (SDO). The reported relationships between SDO and saccadic parameters of main saccade and the effect of aging on SDO are controversial. In addition, it is not clear whether aging-related disease, such as mild cognitive impairment (MCI) and Parkinson disease (PD), causes the specific change of SDO. To address these questions, we analyzed the spatiotemporal features of SDO in young healthy subjects, elderly healthy subjects, and subjects with PD and MCI in three oculomotor tasks. We found two types of SDOs-simple and complex SDO. We confirmed that the frequency and amplitude of SDO were positively correlated with the peak velocity and deceleration of main saccades and increased in elderly subjects; however, they were not significantly different among the three elderly groups. Our results support the previous argument that the oculomotor structure in brainstem and cerebellum directly develop SDO.
扫视眼动可能不会平稳停止，而是会短暂波动，这被称为扫视动态过冲（SDO）。报告的SDO与主要扫视的扫视参数之间的关系以及衰老对SDO的影响存在争议。此外，尚不清楚与衰老相关的疾病，如轻度认知障碍（MCI）和帕金森病（PD），是否会导致SDO的特定变化。为了解决这些问题，我们在三项眼动任务中分析了年轻健康受试者、老年健康受试者以及患有PD和MCI的受试者的SDO时空特征。我们发现了两种类型的SDO——简单SDO和复杂SDO。我们证实，SDO的频率和幅度与主要扫视的峰值速度和减速呈正相关，并且在老年受试者中增加；然而，在三个老年组之间它们没有显著差异。我们的结果支持了先前的观点，即脑干和小脑的眼动结构直接产生SDO。
