Department of Psychology and the Gonda Brain Research Center, Bar Ilan University, 5290002, Ramat Gan, Israel.
, M.B. 87, 99833, Nehusha, Israel.
Neuropsychol Rev. 2018 Mar;28(1):16-31. doi: 10.1007/s11065-017-9362-4. Epub 2017 Oct 27.
Persons with Mild Cognitive Impairment (MCI) are at high Alzheimer's Disease (AD) risk but the development of sensitive measures to assess subtle cognitive decline in this population poses a major challenge for clinicians and researchers. Eye movement monitoring is a non-invasive, sensitive way to assess subtle cognitive processes in clinical populations. We conducted a critical review and a meta-analysis of the literature on pro and antisaccade paradigm in AD/MCI. The meta-analysis included 20 studies, all of which used the prosaccade paradigm and 13 of which studied the antisaccade paradigm as well. Our meta-analysis showed that AD but not MCI patients showed longer prosaccade latencies when compared to controls. While antisaccade latencies did not differentiate between patients from controls, antisaccade error rate were significantly increased among patients in comparison to controls in over 87% of the studies. These findings highlight antisaccade error rate as a reliable tool to distinguish inhibition abilities between AD/MCI and healthy older persons.
轻度认知障碍 (MCI) 患者患阿尔茨海默病 (AD) 的风险较高，但开发敏感的措施来评估该人群的认知能力细微下降对临床医生和研究人员来说是一个重大挑战。眼动监测是一种非侵入性、敏感的方法，可用于评估临床人群中的认知过程。我们对 AD/MCI 中赞成和反对扫视范式的文献进行了批判性回顾和荟萃分析。荟萃分析包括 20 项研究，所有研究均使用了赞成扫视范式，其中 13 项研究也研究了反对扫视范式。我们的荟萃分析表明，与对照组相比，AD 患者而不是 MCI 患者的赞成扫视潜伏期更长。虽然反对扫视潜伏期不能区分患者与对照组，但在超过 87%的研究中，与对照组相比，患者的反对扫视错误率显著增加。这些发现强调了反对扫视错误率作为区分 AD/MCI 和健康老年人抑制能力的可靠工具。
