[肌动蛋白调节骨组织细胞机制的研究进展]
[Research progress on mechanism of myokines regulating bone tissue cells].
作者信息
Peng Hongcheng, Hua Zhen, Yang Huilin, Wang Jianwei
机构信息
Nanjing University of Traditional Chinese Medicine, Nanjing Jiangsu, 210023, P.R.China.
Department of Orthopedics and Traumatology, Wuxi Affiliated Hospital, Nanjing University of Traditional Chinese Medicine, Wuxi Jiangsu, 214071, P.R.China.
出版信息
Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi. 2021 Jul 15;35(7):923-929. doi: 10.7507/1002-1892.202012062.
OBJECTIVE
To review the effects and mechanisms of various myokines secreted by skeletal muscle on various bone tissue cells.
METHODS
Literature related to myokines and their regulation of bone tissue cells was reviewed and analyzed comprehensively in recent years.
RESULTS
Bone and skeletal muscle are important members of the motor system, and they are closely related in anatomy, genetics, and physiopathology. In recent years, it has been found that skeletal muscle can secrete a variety of myokines to regulate bone marrow mesenchymal stem cells, osteoblasts, osteoclasts, and bone cells; these factors mutual crosstalk between myoskeletal unit, contact each other and influence each other, forming a complex myoskeletal micro-environment, and to some extent, it has a positive impact on bone repair and reconstruction.
CONCLUSION
Myokines are potential targets for the dynamic balance of bone tissue cells. In-depth study of its mechanism is helpful to the prevention and treatment of myoskeletal diseases.
目的
综述骨骼肌分泌的各种肌动蛋白对各种骨组织细胞的作用及机制。
方法
对近年来与肌动蛋白及其对骨组织细胞的调节相关的文献进行全面综述和分析。
结果
骨骼和骨骼肌是运动系统的重要组成部分，它们在解剖学、遗传学和生理病理学上密切相关。近年来发现，骨骼肌可分泌多种肌动蛋白来调节骨髓间充质干细胞、成骨细胞、破骨细胞和骨细胞；这些因子在肌骨骼单元之间相互串扰，相互接触并相互影响，形成复杂的肌骨骼微环境，在一定程度上对骨修复和重建有积极影响。
结论
肌动蛋白是骨组织细胞动态平衡的潜在靶点。深入研究其机制有助于肌骨骼疾病的防治。
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