鸢尾素的产生、检测及其来源及其对骨细胞的作用。

The production, detection, and origin of irisin and its effect on bone cells.

机构信息

Department of Orthodontics, Tianjin Medical University School of Stomatology, 22 Qixiangtai Road, Heping District, Tianjin 300070, China.

Department of Spine Surgery, Tianjin Hospital, 406 Jiefang South Road, Hexi District, Tianjin 300211, China.

出版信息

Int J Biol Macromol. 2021 May 1;178:316-324. doi: 10.1016/j.ijbiomac.2021.02.181. Epub 2021 Feb 27.

DOI:10.1016/j.ijbiomac.2021.02.181

PMID:33652046

Abstract

Irisin is a muscle factor discovered in 2012 that plays an important role in many tissues, including bone. Eight years since its discovery, there are still many controversies regarding its molecular biology, detection, and effects on bone. This article summarizes the points raised to date, and discusses the mechanisms by which irisin regulates bone cells. The information reviewed here provides a useful foundation for future research.

摘要

鸢尾素是 2012 年发现的一种肌肉因子，在包括骨骼在内的许多组织中发挥着重要作用。自发现以来已经 8 年了，但其分子生物学、检测及其对骨骼的影响仍存在许多争议。本文总结了迄今为止提出的观点，并讨论了鸢尾素调节骨细胞的机制。本文综述的信息为未来的研究提供了有用的基础。