Department of Radiology, Graduate School of Medicine, University of Tokyo, Bunkyo-ku, Tokyo, Japan.
J Alzheimers Dis. 2021;83(1):281-290. doi: 10.3233/JAD-210596.
Scan acceleration techniques, such as parallel imaging, can reduce scan times, but reliability is essential to implement these techniques in neuroimaging.
To evaluate the reproducibility of the longitudinal changes in brain morphology determined by longitudinal voxel-based morphometry (VBM) between non-accelerated and accelerated magnetic resonance images (MRI) in normal aging, mild cognitive impairment (MCI), and Alzheimer's disease (AD).
Using data from the Alzheimer's Disease Neuroimaging Initiative (ADNI) 2 database, comprising subjects who underwent non-accelerated and accelerated structural T1-weighted MRI at screening and at a 2-year follow-up on 3.0 T Philips scanners, we examined the reproducibility of longitudinal gray matter volume changes determined by longitudinal VBM processing between non-accelerated and accelerated imaging in 50 healthy elderly subjects, 54 MCI patients, and eight AD patients.
The intraclass correlation coefficient (ICC) maps differed among the three groups. The mean ICC was 0.72 overall (healthy elderly, 0.63; MCI, 0.75; AD, 0.63), and the ICC was good to excellent (0.6-1.0) for 81.4%of voxels (healthy elderly, 64.8%; MCI, 85.0%; AD, 65.0%). The differences in image quality (head motion) were not significant (Kruskal-Wallis test, p = 0.18) and the within-subject standard deviations of longitudinal gray matter volume changes were similar among the groups.
The results indicate that the reproducibility of longitudinal gray matter volume changes determined by VBM between non-accelerated and accelerated MRI is good to excellent for many regions but may vary between diseases and regions.
扫描加速技术，如并行成像，可以减少扫描时间，但在神经影像学中实施这些技术的可靠性是至关重要的。
评估非加速和加速磁共振成像（MRI）之间基于体素的形态测量学（VBM）纵向测量脑形态变化的重复性在正常老化、轻度认知障碍（MCI）和阿尔茨海默病（AD）中的表现。
利用来自阿尔茨海默病神经影像学倡议（ADNI）2 数据库的数据，包括在 3.0T 飞利浦扫描仪上进行非加速和加速结构 T1 加权 MRI 筛查和 2 年随访的受试者，我们研究了 50 名健康老年人、54 名 MCI 患者和 8 名 AD 患者在非加速和加速成像之间的纵向灰质体积变化的重复性，这些变化是通过纵向 VBM 处理确定的。
组内相关系数（ICC）图在三组之间存在差异。总的来说，平均 ICC 为 0.72（健康老年人为 0.63；MCI 为 0.75；AD 为 0.63），81.4%的体素（健康老年人为 64.8%；MCI 为 85.0%；AD 为 65.0%）的 ICC 为良好至优秀（0.6-1.0）。图像质量（头部运动）的差异不显著（Kruskal-Wallis 检验，p=0.18），各组间纵向灰质体积变化的个体内标准差相似。
结果表明，非加速和加速 MRI 之间 VBM 确定的纵向灰质体积变化的重复性对于许多区域来说是良好至优秀的，但可能因疾病和区域而异。
