Takao Hidemasa, Amemiya Shiori, Abe Osamu
Department of Radiology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan.
J Magn Reson Imaging. 2022 Apr;55(4):1151-1160. doi: 10.1002/jmri.27929. Epub 2021 Sep 23.
Scan acceleration such as parallel imaging reduces scan time, but shorter scan time may reduce the signal-to-noise ratio and affect image quality. The reproducibility of longitudinal changes in the brain structure between non-accelerated and accelerated imaging by surface-based analysis is unclear.
To determine the reproducibility of longitudinal changes in cortical thickness, measured by surface-based morphometry, between non-accelerated and accelerated structural T -weighted imaging in the healthy elderly and those with mild cognitive impairment (MCI) and Alzheimer's disease (AD).
Retrospective.
Fifty healthy elderly subjects (age = 73 ± 5 years, 29 females, 21 males), 54 MCI patients (age = 71 ± 7 years, 23 females, 31 males), and 8 AD patients (age = 78 ± 6 years, 6 females, 2 males).
FIELD STRENGTH/SEQUENCE: 3 T, magnetization-prepared rapid gradient-echo.
Longitudinal changes in cortical thickness estimated by the longitudinal stream in FreeSurfer from 2-year interval data, and visual assessment of image quality by three radiologists.
Intraclass correlation coefficient (ICC) and Kruskal-Wallis test. A P value <0.05 was considered significant.
Healthy elderly subjects, MCI patients, and AD patients showed different patterns in the ICC maps. For the smoothing of 20 mm full width at half maximum, the mean ICC was 0.45 overall (healthy elderly, 0.33; MCI patients, 0.49; AD patients, 0.31). The within-subject SDs of the symmetrized percent changes were similar between healthy elderly subjects (mean, 1.3%/year) and MCI patients (mean, 1.3%/year) but larger in AD patients (mean, 1.7%/year). Image quality did not significantly differ per group (P = 0.18).
The results of this study indicate the reproducibility of longitudinal changes in cortical thickness measured by surface-based morphometry between non-accelerated and accelerated imaging, and that the reproducibility varies by disease and region.
3 TECHNICAL EFFICACY: Stage 1.
诸如并行成像之类的扫描加速可缩短扫描时间，但较短的扫描时间可能会降低信噪比并影响图像质量。通过基于表面的分析来评估非加速成像和加速成像之间脑结构纵向变化的可重复性尚不清楚。
确定在健康老年人、轻度认知障碍（MCI）患者和阿尔茨海默病（AD）患者中，通过基于表面的形态学测量的皮质厚度纵向变化在非加速和加速结构T加权成像之间的可重复性。
回顾性研究。
50名健康老年人（年龄=73±5岁，女性29名，男性21名），54名MCI患者（年龄=71±7岁，女性23名，男性31名），以及8名AD患者（年龄=78±6岁，女性6名，男性2名）。
场强/序列：3T，磁化准备快速梯度回波。
通过FreeSurfer中的纵向流程根据两年间隔数据估计皮质厚度的纵向变化，并由三名放射科医生对图像质量进行视觉评估。
组内相关系数（ICC）和Kruskal-Wallis检验。P值<0.05被认为具有统计学意义。
健康老年人、MCI患者和AD患者在ICC图中呈现出不同的模式。对于半高全宽为20mm的平滑处理，总体平均ICC为0.45（健康老年人为0.33；MCI患者为0.49；AD患者为0.31）。对称百分比变化的受试者内标准差在健康老年人（平均每年1.3%）和MCI患者（平均每年1.3%）之间相似，但在AD患者中更大（平均每年1.7%）。各组之间的图像质量无显著差异（P=0.18）。
本研究结果表明，通过基于表面的形态学测量的皮质厚度纵向变化在非加速和加速成像之间具有可重复性，且可重复性因疾病和区域而异。
3级 技术效能：1级
