Tomoda H, Furusawa M
Department of Gastroenterological Surgery, National Kyushu Cancer Center, Fukuoka, Japan.
Jpn J Surg. 1987 Sep;17(5):348-53. doi: 10.1007/BF02470633.
The family history of colorectal cancer was examined in 601 patients with non-polypotic colorectal cancer. 33 (5.5 per cent) of these patients were found to have a family history. Colorectal cancer was found significantly more often in the families of those patients with the disease rather than in those with gastric cancer (5.5 per cent vs 3.0 per cent). The mean age was younger by five years in the patients with a family history than in those with no family history. The incidence of young patients, multiple cancers, and other cancers in relatives was significantly higher in the patients with a family history than in those without. No significant difference in cancer sites between the two groups was seen, however, there was a preponderance of right colon cancers in the young patients with a family history. There was one particular patient with seven affected relatives in his family. In this patient, an early age of onset, the presence of multiple cancers, including a right colon cancer, the occurrence of metachronous other cancers and the fact that one of his relatives was accidentally found to have an occult colon cancer were noteworthy. It is important to survey the family members of patients, especially the young ones, where there is a family history of colorectal cancer.
对601例非息肉病性结直肠癌患者的家族史进行了调查。其中33例（5.5%）患者有家族史。结直肠癌患者家族中患结直肠癌的比例明显高于胃癌患者家族（5.5%对3.0%）。有家族史的患者平均年龄比无家族史的患者小5岁。有家族史的患者中年轻患者、亲属患多种癌症及其他癌症的发生率明显高于无家族史者。两组之间癌症部位无显著差异，然而，有家族史的年轻患者中右半结肠癌占优势。有一名患者，其家族中有7名亲属患病。该患者发病年龄早、患有多种癌症（包括右半结肠癌）、出现异时性其他癌症，且其一名亲属意外发现患有隐匿性结肠癌，这些情况值得关注。对有结直肠癌家族史的患者，尤其是年轻患者的家庭成员进行调查很重要。
