Soliman A S, Bondy M L, Levin B, El-Badawy S, Khaled H, Hablas A, Ismail S, Adly M, Mahgoub K G, McPherson R S, Beasley R P
Department of Community Medicine, Menofeia Faculty of Medicine, Egypt.
Int J Cancer. 1998 Sep 11;77(6):811-6. doi: 10.1002/(sici)1097-0215(19980911)77:6<811::aid-ijc1>3.0.co;2-x.
We have investigated the familial aggregation of colorectal cancer and hereditary nonpolyposis colorectal cancer (HNPCC) in Egypt because of the high incidence of colorectal cancer in Egyptian children and young adults and the prevalence of consanguinity there. In a pilot study, we conducted detailed interviews with 111 Egyptian colorectal cancer patients and 111 healthy Egyptian controls about their family histories of colorectal cancer, and other cancers, consanguinity, age at diagnosis, symptoms and recurrence. Eight patients (7.2%) had one or more first- or second-degree relatives under age 40 with colorectal cancer, suggestive of HNPCC by the Amsterdam criteria. One of these families had a typical history of HNPCC, with 4 relatives having colorectal cancer in 3 generations; 3 of these relatives were younger than age 45 at colon cancer diagnosis, and other relatives had extracolonic tumors. Another 14 patients (12.6%) had a first- or second-degree relative with a family history of other neoplasms such as endometrial, urinary and hepatobiliary cancers that could also be related to HNPCC. Four patients with early-onset colon cancer and a family history of other HNPCC-related cancers reported that their parents were first-degree cousins.
由于埃及儿童和年轻人中结直肠癌的高发病率以及当地近亲结婚的普遍情况，我们对埃及结直肠癌和遗传性非息肉病性结直肠癌（HNPCC）的家族聚集性进行了调查。在一项初步研究中，我们对111名埃及结直肠癌患者和111名健康埃及对照者进行了详细访谈，内容涉及他们的结直肠癌家族史、其他癌症家族史、近亲结婚情况、诊断年龄、症状和复发情况。8名患者（7.2%）有一名或多名40岁以下的一级或二级亲属患有结直肠癌，根据阿姆斯特丹标准提示为HNPCC。其中一个家族有典型的HNPCC病史，三代中有4名亲属患有结直肠癌；这些亲属中有3人在结肠癌诊断时年龄小于45岁，其他亲属患有结肠外肿瘤。另外14名患者（12.6%）有一名一级或二级亲属有其他肿瘤家族史，如子宫内膜癌、泌尿系统癌和肝胆系统癌，这些也可能与HNPCC有关。4名早发性结肠癌患者且有其他HNPCC相关癌症家族史的患者报告称，他们的父母是一级表亲。
