Department of Cardiology, Van Training and Research Hospital, Health Science University, Van, Turkey.
Acta Cardiol. 2022 Jul;77(5):449-455. doi: 10.1080/00015385.2021.1954747. Epub 2021 Jul 26.
The presence of intracoronary thrombus is associated with adverse events in patients with ST-segment elevation myocardial infarction (STEMI). PRECISE-DAPT score is used to detect the bleeding risk in STEMI patients who are on dual antiplatelet therapy. Recently, the PRECISE-DAPT score was shown to be related to cardiovascular events. We aimed to investigate the association of PRECISE-DAPT score with thrombus burden in patients with STEMI.
A retrospective analysis with 204 STEMI patients undergoing primary percutaneous coronary intervention was conducted in this study. Thrombus burden grade and PRECISE-DAPT score were calculated for each subject. Patients were divided into two groups as high thrombus burden (HTB) (grade 4, 5) and low thrombus burden (LTB) (grade 1, 2 and 3) based on thrombus burden grade. The PRECISE-DAPT scores were compared between thrombus burden groups.
The mean age in HTB ( = 136) was 63.7 (11.3), and 64.7% were male. HTB had a higher PRECISE-DAPT score than LTB ( < .0001). PRECISE-DAPT score, baseline troponin I levels, ejection fraction, and pain to balloon time were independent predictors of HTB.
PRECISE-DAPT score was an independent predictor of HTB in patients with STEMI.
ST 段抬高型心肌梗死（STEMI）患者冠状动脉内血栓的存在与不良事件相关。PRECTSE-DAPT 评分用于检测接受双联抗血小板治疗的 STEMI 患者的出血风险。最近，PRECTSE-DAPT 评分与心血管事件相关。我们旨在研究 PRECISE-DAPT 评分与 STEMI 患者血栓负荷的关系。
本研究回顾性分析了 204 例接受直接经皮冠状动脉介入治疗的 STEMI 患者。为每位患者计算血栓负荷分级和 PRECISE-DAPT 评分。根据血栓负荷分级，将患者分为高血栓负荷（HTB）（等级 4、5）和低血栓负荷（LTB）（等级 1、2 和 3）两组。比较血栓负荷组之间的 PRECISE-DAPT 评分。
在 HTB 组（n=136），平均年龄为 63.7（11.3）岁，64.7%为男性。HTB 的 PRECISE-DAPT 评分高于 LTB（<0.0001）。PRECISE-DAPT 评分、基线肌钙蛋白 I 水平、射血分数和疼痛至球囊时间是 HTB 的独立预测因子。
在 STEMI 患者中，PRECISE-DAPT 评分是 HTB 的独立预测因子。
