Coşkun Gökhan, Ozde Cem, Kayapinar Osman, Aktore Gulsah, Ekşi Ensar, Afşin Hamdi, Sayın Ahmet Egemen
Düzce Üniversitesi Tip Fakültesi, Duzce, Turkey.
Duzce Universitesi, Duzce, Turkey.
Clin Appl Thromb Hemost. 2024 Jan-Dec;30:10760296241237232. doi: 10.1177/10760296241237232.
The anticoagulation and risk factors in atrial fibrillation (ATRIA) score is associated with adverse cardiovascular events. However, its relationship with coronary thrombus burden is unclear. Therefore, we aimed to investigate the relationship between the ATRIA score and thrombus burden in patients with ST-segment elevation myocardial infarction (STEMI) who underwent percutaneous coronary intervention (PCI).
The study was designed as a prospective cross-sectional observational study. Our study included 319 patients who were prospectively admitted with STEMI between January 2021 and April 2022. Patients were divided into 2 groups with low thrombus burden (LTB) (grade <3) and high thrombus burden (HTB) (grade ≥3). ATRIA score was calculated and recorded for all patients. ATRIA scores of both groups were compared.
In our study, 58.9% ( = 188) of patients in the LTB group and 41% ( = 131) of patients in the HTB group. The ATRIA risk score (< .001) was significantly higher in the HTB group. In multivariate logistic regression analysis, ATRIA score, glomerular filtration rate, hypertensıon, abciximab usage, and no-reflow were found to be independent predictors of HTB in STEMI patients undergoing primary PCI. In receiver operating characteristic analysis, ATRIA score >4 had a sensitivity of 66.2% and specificity of 95.2%, and ATRIA score >8 sensitivity of 98% and specificity of 100% predicted HTB.
In this study, we found that thrombus burden may be associated with ATRIA risk score in patients presenting with STEMI.
心房颤动抗凝与危险因素（ATRIA）评分与不良心血管事件相关。然而，其与冠状动脉血栓负荷的关系尚不清楚。因此，我们旨在研究接受经皮冠状动脉介入治疗（PCI）的ST段抬高型心肌梗死（STEMI）患者的ATRIA评分与血栓负荷之间的关系。
本研究设计为前瞻性横断面观察性研究。我们的研究纳入了2021年1月至2022年4月期间前瞻性收治的319例STEMI患者。患者分为低血栓负荷（LTB）组（分级<3）和高血栓负荷（HTB）组（分级≥3）。计算并记录所有患者的ATRIA评分。比较两组的ATRIA评分。
在我们的研究中，LTB组58.9%（n = 188）的患者和HTB组41%（n = 131）的患者。HTB组的ATRIA风险评分（<0.001）显著更高。在多因素逻辑回归分析中，发现ATRIA评分、肾小球滤过率、高血压、阿昔单抗使用情况和无复流是接受直接PCI的STEMI患者HTB的独立预测因素。在受试者工作特征分析中，ATRIA评分>4时预测HTB的敏感性为66.2%，特异性为95.2%，ATRIA评分>8时敏感性为98%，特异性为100%。
在本研究中，我们发现STEMI患者的血栓负荷可能与ATRIA风险评分相关。
