Department of Medical Research, Taipei Veterans General Hospital, Taipei, Taiwan.
Department of Otolaryngology-Head and Neck Surgery, Taipei Veterans General Hospital, Taipei, Taiwan.
Eur Arch Otorhinolaryngol. 2021 Nov;278(11):4315-4319. doi: 10.1007/s00405-021-07014-x. Epub 2021 Jul 26.
Few studies have explored population-based incidence rates of microtia using nationwide data. The aim of this study was to analyze the 10-year secular trends in the incidence of microtia and/or anotia in Taiwan from 2008 to 2017 using nationwide population-based data.
Patient data were retrieved from Taiwan's National Health Insurance Dataset, after identifying 1152 children aged ≤ 1 year with a first-time diagnosis of microtia or anotia between January 2008 and December 2017. The annual microtia-anotia incidence rate was the sum of new microtia-anotia cases in a year divided by total infant population in the year. Furthermore, we used the annual percent change (APC) to study the secular trend in microtia-anotia incidence rate.
The annual incidence rate of microtia-anotia averaged across the 10-year period was 57.7 per 100,000 infants (standard deviation = 8.6). The annual incidence rates of microtia and anotia were 53.3 and 4.4 per 100,000 infants, respectively, during this period. Furthermore, female infants had a higher incidence than males (63.3 vs. 52.4 per 100,000). The incidence of microtia-anotia gradually decreased between 2008 and 2017 with an APC of - 5.64% (95% CI - 9.31 ~ - 1.18%, p = 0.004). Since 2011, females had a significantly higher annual incidence rate of microtia-anotia than males.
The incidence of microtia-anotia was 57.7 per 100,000 infants in Taiwan, which declined during the study period 2008-2017. The female-to-male incidence ratio was 1.21:1.
利用全国性数据，很少有研究探讨基于人群的小耳畸形发病率。本研究旨在利用全国性基于人群的数据，分析 2008 年至 2017 年台湾小耳畸形和/或无耳畸形的 10 年发病趋势。
从台湾全民健康保险数据库中检索患者数据，确定 2008 年 1 月至 2017 年 12 月期间，1152 名年龄≤1 岁的儿童首次诊断为小耳畸形或无耳畸形。小耳畸形-无耳畸形的年发病率是当年新小耳畸形-无耳畸形病例数之和除以当年婴儿总人口。此外，我们使用年百分比变化（APC）来研究小耳畸形-无耳畸形发病率的时间趋势。
10 年期间小耳畸形-无耳畸形的年平均发病率为 57.7/10 万婴儿（标准差=8.6）。在此期间，小耳畸形和无耳畸形的年发病率分别为 53.3/10 万婴儿和 4.4/10 万婴儿。此外，女性婴儿的发病率高于男性（63.3 比 52.4/10 万）。2008 年至 2017 年期间，小耳畸形-无耳畸形的发病率逐渐下降，APC 为-5.64%（95%CI-9.31~-1.18%，p=0.004）。自 2011 年以来，女性小耳畸形-无耳畸形的年发病率明显高于男性。
台湾小耳畸形-无耳畸形的发病率为 57.7/10 万婴儿，在 2008-2017 年研究期间呈下降趋势。女性与男性的发病率比为 1.21:1。
