Song Ruixue, Pan Kuan-Yu, Xu Hui, Qi Xiuying, Buchman Aron S, Bennett David A, Xu Weili
Department of Epidemiology and Biostatistics, School of Public Health, Tianjin Medical University, Tianjin, China.
Tianjin Key Laboratory of Environment, Nutrition and Public Health, Tianjin, China.
Alzheimers Dement. 2021 Dec;17(12):1914-1922. doi: 10.1002/alz.12343. Epub 2021 Jul 26.
The impact of cardiovascular risk burden on brain pathologies remains unclear. We aimed to examine the association of the Framingham General Cardiovascular Risk Score (FGCRS) with dementia risk, and brain pathologies.
Within the Rush Memory and Aging Project, 1588 dementia-free participants were assessed on FGCRS at baseline and followed up to 21 years. During the follow-up, 621 participants died and underwent autopsies.
The multi-adjusted hazard ratios (HRs) (95% confidence intervals [CIs]) of FGCRS were 1.03 (1.00-1.07) for dementia and 1.04 (1.01-1.07) for Alzheimer's disease (AD) dementia. Further, a higher FGCRS was associated with higher gross chronic cerebral infarctions (odds ratio [OR] 1.08, 95% CI 1.02-1.14), cerebral atherosclerosis (OR 1.10, 95% CI 1.03-1.17), and global AD pathology (OR 1.06, 95% CI 1.01-1.12).
A higher FGCRS is associated with an increased risk of dementia and AD dementia. Both vascular and AD pathologies in the brain may underlie this association.
心血管风险负担对脑部病变的影响仍不明确。我们旨在研究弗雷明汉综合心血管风险评分（FGCRS）与痴呆风险及脑部病变之间的关联。
在拉什记忆与衰老项目中，1588名无痴呆症的参与者在基线时接受了FGCRS评估，并随访了21年。在随访期间，621名参与者死亡并接受了尸检。
FGCRS的多因素调整风险比（HRs）（95%置信区间[CIs]）对于痴呆症为1.03（1.00 - 1.07），对于阿尔茨海默病（AD）痴呆症为1.04（1.01 - 1.07）。此外，较高的FGCRS与更高的慢性脑梗死总发生率（优势比[OR] 1.08，95% CI 1.02 - 1.14）、脑动脉粥样硬化（OR 1.10，95% CI 1.03 - 1.17）以及全球AD病理学特征（OR 1.06，95% CI 1.01 - 1.12）相关。
较高的FGCRS与痴呆症和AD痴呆症风险增加相关。脑部的血管病变和AD病变可能是这种关联的基础。
