Department of Neurology, University of California, San Francisco, Memory and Aging Center, San Francisco, California, USA.
Department of Psychology, Palo Alto University, Palo Alto, California, United States.
Alzheimers Dement. 2024 Oct;20(10):6820-6833. doi: 10.1002/alz.14172. Epub 2024 Sep 6.
Cardiovascular health is important for brain aging, yet its role in the clinical manifestation of autosomal dominant or atypical forms of dementia has not been fully elucidated. We examined relationships between Life's Simple 7 (LS7) and clinical trajectories in individuals with autosomal dominant frontotemporal lobar degeneration (FTLD).
Two hundred forty-seven adults carrying FTLD pathogenic genetic variants (53% asymptomatic) and 189 non-carrier controls completed baseline LS7, and longitudinal neuroimaging and neuropsychological testing.
Among variant carriers, higher baseline LS7 is associated with slower accumulation of frontal white matter hyperintensities (WMHs), as well as slower memory and language declines. Higher baseline LS7 associated with larger baseline frontotemporal volume, but not frontotemporal volume trajectories.
Better baseline cardiovascular health related to slower cognitive decline and accumulation of frontal WMHs in autosomal dominant FTLD. Optimizing cardiovascular health may be an important modifiable approach to bolster cognitive health and brain integrity in FTLD.
Better cardiovascular health associates with slower cognitive decline in frontotemporal lobar degeneration (FTLD). Lifestyle relates to the accumulation of frontal white matter hyperintensities in FTLD. More optimal cardiovascular health associates with greater baseline frontotemporal lobe volume. Optimized cardiovascular health relates to more favorable outcomes in genetic dementia.
心血管健康对大脑衰老很重要，但它在常染色体显性或非典型形式的痴呆症的临床表现中的作用尚未完全阐明。我们研究了 Life's Simple 7（LS7）与携带常染色体显性额颞叶变性（FTLD）的个体的临床轨迹之间的关系。
247 名携带 FTLD 致病基因突变的成年人（53%无症状）和 189 名非携带者对照者完成了 LS7 的基线测试，以及纵向神经影像学和神经心理学测试。
在变异携带者中，较高的 LS7 基线与额叶白质高信号（WMH）的积累速度较慢，以及记忆和语言下降速度较慢有关。较高的 LS7 基线与较大的额颞叶体积相关，但与额颞叶体积轨迹无关。
更好的基线心血管健康与常染色体显性 FTLD 认知能力下降和额叶 WMH 积累速度较慢有关。优化心血管健康可能是增强 FTLD 认知健康和大脑完整性的重要可改变方法。
更好的心血管健康与额颞叶变性（FTLD）认知能力下降速度较慢有关。生活方式与 FTLD 额叶白质高信号的积累有关。更优化的心血管健康与更大的额颞叶基线体积有关。优化的心血管健康与遗传痴呆症的更有利结果有关。
