Institute for Translational Research, University of North Texas Health Science Center, Fort Worth, Texas, USA.
Department of Family Medicine, University of North Texas Health Science Center, Fort Worth, Texas, USA.
Alzheimers Dement. 2022 Feb;18(2):240-250. doi: 10.1002/alz.12404. Epub 2021 Jul 26.
No large-scale characterizations of neurofilament light chain (NfL) have been conducted in diverse populations.
Baseline data were analyzed among n = 890 Mexican Americans and n = 813 non-Hispanic Whites from the multi-ethnic Health & Aging Brain among Latino Elders (HABLE) study. Plasma NfL was measured on the Simoa platform.
In unadjusted models, NfL was significantly associated with age (P < .001), hypertension (P < .001), dyslipidemia (P = .02), and diabetes (P < .001). Covarying for age and sex, NfL was associated with neurodegeneration (P < .001) and global amyloid burden levels (P = .02) in a subset with available data. NfL levels were significantly associated with diagnostic groups (Normal Cognition [NC], mild cognitive impairment [MCI], Dementia; P < .001); however, there was no cut-score that yielded acceptable diagnostic accuracy. NfL levels produced a sensitivity of 0.60 and specificity of 0.78 with negative predictive value of 89% for detecting amyloid positivity.
Plasma NfL levels are significantly impacted by age and medical co-morbidities that are common among older adults, which complicate its utility as a diagnostic biomarker.
尚未在不同人群中对神经丝轻链（NfL）进行大规模特征描述。
对来自拉丁裔老年人多民族健康与衰老大脑研究（HABLE）的 n=890 名墨西哥裔美国人和 n=813 名非西班牙裔白人的基线数据进行了分析。使用 Simoa 平台测量血浆 NfL。
在未调整的模型中，NfL 与年龄（P<.001）、高血压（P<.001）、血脂异常（P=.02）和糖尿病（P<.001）显著相关。在具有可用数据的亚组中，共变量为年龄和性别，NfL 与神经退行性变（P<.001）和总淀粉样蛋白负担水平（P=.02）相关。NfL 水平与诊断组（正常认知[NC]、轻度认知障碍[MCI]、痴呆）显著相关（P<.001）；然而，没有产生可接受的诊断准确性的切分值。NfL 水平的检测灵敏度为 0.60，特异性为 0.78，阴性预测值为 89%，用于检测淀粉样蛋白阳性。
血浆 NfL 水平受年龄和老年人群中常见的合并症的显著影响，这使其作为诊断生物标志物的实用性变得复杂。
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