神经丝轻链（NfL）与认知表现的关系：一项墨西哥裔美国人正常认知、轻度认知障碍和痴呆症样本研究。
Relationship of Neurofilament Light (NfL) and Cognitive Performance in a Sample of Mexican Americans with Normal Cognition, Mild Cognitive Impairment and Dementia.
机构信息
Institute for Translational Research, University of North Texas Health Science Center, Fort Worth, TX, United States.
出版信息
Curr Alzheimer Res. 2020;17(13):1214-1220. doi: 10.2174/1567205018666210219105949.
INTRODUCTION
This study characterized the relationship between plasma NfL and cognition in a community-based sample of older Mexican Americans.
METHODS
544 participants completed a battery of neuropsychological tests and were diagnosed using clinical criteria. NfL was assayed using Simoa. NfL levels across groups and tests were analyzed.
RESULTS
Difference in NfL was found between normal and impaired groups and was related to global cognition, processing speed, executive functions and a list of learning tasks with a significant negative effect for all diagnostic groups. NfL had a negative impact on processing speed, attention, executive functions and delayed and recognition memory for both normal and MCI groups.
CONCLUSION
The research supports plasma NfL as a marker of cognitive impairment related to neurodegenerative processes in Mexican Americans and may be a marker of early changes in cognition in those with normal cognition and at risk for developing MCI.
简介
本研究在一个基于社区的墨西哥裔美国老年人样本中，描述了血浆 NfL 与认知之间的关系。
方法
544 名参与者完成了一系列神经心理学测试，并根据临床标准进行了诊断。使用 Simoa 测定 NfL。分析了各组和各测试之间的 NfL 水平。
结果
在正常组和受损组之间发现了 NfL 的差异，并且与整体认知、处理速度、执行功能以及一系列学习任务有关，所有诊断组的结果均为显著负相关。NfL 对正常组和 MCI 组的处理速度、注意力、执行功能以及延迟和识别记忆均有负面影响。
结论
该研究支持血浆 NfL 作为与墨西哥裔美国人神经退行性过程相关的认知障碍的标志物，并且可能是那些认知正常且有发展为 MCI 风险的人的认知早期变化的标志物。
Zotero 插件