Ann Ital Chir. 2021;92:227-233.
Parathyroid carcinoma (PC) represents a rare cause of primary hyperparathyroidism (PHPT). In this paper, among patients who underwent surgery for PHPT, we compared those with benign parathyroid disease with those affected by PC in terms of demographic and preoperative biochemical features. Moreover, we singularly described all 10 cases of PC treated at our Institution (including a case that occurred in a patient with tertiary hyperparathyroidism) and a brief review of the literature.
Patients undergoing surgery for PHPT in our Unit between 2003 and 2018 were retrospectively analysed. They were divided into two groups: Group A (benign parathyroid disease), Group B (PC). The case of PC that occurred in the patient with tertiary hyperparathyroidism was not included into the two groups.
Three hundred and eight patients were included: 299 in Group A and 9 in Group B. The mean preoperative serum PTH value and mean preoperative serum calcium level were significantly higher in Group B than in Group A (P = 0.018, P = 0.027; respectively). Including the case of PC that occurred in the patient with tertiary hyperparathyroidism, 10 patients with PC were treated at our Institution. Among these, 3 underwent a re-exploration. Disease recurrence occurred in 1 (10%) patient, who developed a local recurrence and distant metastases.
In the presence of PHPT characterized by particularly high preoperative levels of serum PTH and calcium this malignancy should be suspected. On the basis of our experience, we believe that extensive surgery is not always necessary.
Hyperparathyroidism, Parathyroid carcinoma, Parathyroid surgery.
甲状旁腺癌（PC）是原发性甲状旁腺功能亢进症（PHPT）的罕见病因。在本文中，我们比较了在接受 PHPT 手术的患者中，患有良性甲状旁腺疾病的患者与患有 PC 的患者在人口统计学和术前生化特征方面的差异。此外，我们还单独描述了在我院治疗的 10 例 PC 病例（包括一例发生在三发性甲状旁腺功能亢进症患者中的病例），并对文献进行了简要回顾。
回顾性分析了我院 2003 年至 2018 年间接受 PHPT 手术的患者。他们被分为两组：A 组（良性甲状旁腺疾病）和 B 组（PC）。在三发性甲状旁腺功能亢进症患者中发生的 PC 病例不包括在这两组中。
共纳入 308 例患者：A 组 299 例，B 组 9 例。B 组患者术前血清 PTH 值和血清钙水平均明显高于 A 组（P = 0.018，P = 0.027）。包括在三发性甲状旁腺功能亢进症患者中发生的 PC 病例，我院共治疗了 10 例 PC 患者。其中 3 例进行了再次探查。1 例（10%）患者复发，发生局部复发和远处转移。
在存在术前血清 PTH 和钙水平特别高的 PHPT 时，应怀疑存在这种恶性肿瘤。根据我们的经验，我们认为广泛的手术并非总是必要的。
甲状旁腺功能亢进症、甲状旁腺癌、甲状旁腺手术。
