School of Dentistry, China Medical University, Taichung, Taiwan.
Department of Oral and Maxillofacial Surgery, Changhua Christian Hospital, Changhua, Taiwan.
Sci Rep. 2021 Jul 26;11(1):15153. doi: 10.1038/s41598-021-94567-w.
F-fluorodeoxyglucose-positron emission tomography (FDG-PET) is widely used for tumor staging. This study sought to determine the relationship of preoperative primary tumor SUVmax (tSUVmax) with the clinicopathological features of patients with OSCC and to compare the prognostic ability of tSUVmax with that of other recurrence factors. Data of 340 patients with OSCC who were diagnosed, treated, and followed up at the Changhua Christian Hospital were retrospectively analyzed. Only patients with OSCC arising from gingiva, palate, floor of the mouth, and retromolar trigone and those who had received preoperative FDG-PET within 2 weeks before surgery were included. tSUVmax value > 9.2 was the strong predictor of bone invasion (area under the receiver operating characteristic curve, 0.844). tSUVmax value > 7.2 showed a strong association with advanced pathological T stage and recurrence factors and was associated with poor survival; tSUVmax > 7.2 showed stronger predictive power for poor disease-free survival (DFS) than pT stage and the other recurrence factors related to primary tumor. FDG-PET can be a useful supplement to contrast-enhanced computed tomography or contrast-enhanced magnetic resonance imaging for diagnosing bone invasion by OSCC. The tSUVmax value was an independent predictor of DFS in this study.
氟代脱氧葡萄糖正电子发射断层扫描（FDG-PET）广泛用于肿瘤分期。本研究旨在确定术前原发肿瘤 SUVmax（tSUVmax）与口腔鳞状细胞癌（OSCC）患者临床病理特征的关系，并比较 tSUVmax 与其他复发因素的预后能力。回顾性分析了在彰化基督教医院被诊断、治疗和随访的 340 名 OSCC 患者的数据。仅包括起源于牙龈、上颚、口底和磨牙后三角的 OSCC 患者，以及在手术前 2 周内接受过术前 FDG-PET 的患者。tSUVmax 值＞9.2 是骨侵犯的强预测因子（受试者工作特征曲线下面积，0.844）。tSUVmax 值＞7.2 与晚期病理 T 分期和复发因素密切相关，并与不良生存相关；tSUVmax 值＞7.2 对不良无病生存率（DFS）的预测能力强于 pT 分期和与原发肿瘤相关的其他复发因素。FDG-PET 可作为对比增强 CT 或对比增强磁共振成像的有用补充，用于诊断 OSCC 的骨侵犯。在本研究中，tSUVmax 值是 DFS 的独立预测因子。
