Oral and Maxillofacial Surgery, Faculty of Dentistry, The University of Hong Kong, Hong Kong SAR, China.
Department of Anesthesia, Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China.
Head Neck. 2021 Nov;43(11):3662-3680. doi: 10.1002/hed.26824. Epub 2021 Jul 27.
Oral cavity cancer is often described as a lifestyle-related malignancy due to its strong associations with habitual factors, including tobacco use, heavy alcohol consumption, and betel nut chewing. However, patients with no genetically predisposing conditions who do not indulge in these risk habits are still being encountered, albeit less commonly. The aim of this review is to summarize contemporaneous reports on these nonsmoking, nonalcohol drinking (NSND) patients. We performed database searching to identify relevant studies from January 1, 2000 to March 31, 2021. Twenty-six articles from 20 studies were included in this study. We found that these individuals were mostly females in their eighth decade with tumors involving the tongue and gingivobuccal mucosa. This review also observed that these patients were likely diagnosed with early stage tumors with overexpression of programmed death-ligand 1 (PD-L1) and increased intensity of tumor infiltrating lymphocytes. Treatment response and disease-specific prognosis were largely comparable between NSND and smoking/drinking patients.
口腔癌常被描述为与生活方式相关的恶性肿瘤，因为它与习惯性因素有很强的关联，包括吸烟、大量饮酒和咀嚼槟榔。然而，仍有一些没有遗传易感性且不沉溺于这些风险习惯的患者被发现，尽管这种情况较少见。本综述的目的是总结目前关于这些不吸烟、不饮酒（NSND）患者的报告。我们进行了数据库检索，以确定 2000 年 1 月 1 日至 2021 年 3 月 31 日的相关研究。这项研究纳入了 20 项研究中的 26 篇文章。我们发现，这些患者主要为 80 多岁的女性，肿瘤累及舌和龈颊黏膜。本综述还观察到，这些患者的肿瘤可能被诊断为早期，程序性死亡配体 1（PD-L1）表达过度，肿瘤浸润淋巴细胞强度增加。NSND 与吸烟/饮酒患者的治疗反应和疾病特异性预后大致相当。
