出生后 7 至 14 天开始全身给予氢化可的松对通气早产儿在 2 年校正年龄时死亡率和神经发育的影响：一项随机临床试验的随访。
Effect of Systemic Hydrocortisone Initiated 7 to 14 Days After Birth in Ventilated Preterm Infants on Mortality and Neurodevelopment at 2 Years' Corrected Age: Follow-up of a Randomized Clinical Trial.
机构信息
Department of Neonatology, Emma Children's Hospital Amsterdam UMC, Amsterdam, the Netherlands.
Department of Neonatology, Universitair Ziekenhuis Brussel, Jette, Belgium.
出版信息
JAMA. 2021 Jul 27;326(4):355-357. doi: 10.1001/jama.2021.9380.
Abstract
This follow-up to the STOP-BPD randomized clinical trial, which investigated the efficacy and safety of systemic hydrocortisone treatment initiated 7 to 14 days after birth in ventilator-dependent, very preterm infants in the Netherlands and Belgium at 36 weeks’ postmenstrual age, examines the prespecified composite of death and neurodevelopmental impairment among these infants at 2 years’ corrected age.
摘要
这是 STOP-BPD 随机临床试验的后续研究，该研究调查了在荷兰和比利时出生的、依赖呼吸机的极早产儿在出生后 7 至 14 天开始接受全身氢化可的松治疗的疗效和安全性，研究了这些婴儿在 2 岁校正年龄时死亡和神经发育障碍的预先指定复合终点。
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本文引用的文献
1
Effect of Hydrocortisone Therapy Initiated 7 to 14 Days After Birth on Mortality or Bronchopulmonary Dysplasia Among Very Preterm Infants Receiving Mechanical Ventilation: A Randomized Clinical Trial.出生后 7 至 14 天开始给予氢化可的松治疗对接受机械通气的极早产儿死亡率或支气管肺发育不良的影响：一项随机临床试验。
JAMA. 2019 Jan 29;321(4):354-363. doi: 10.1001/jama.2018.21443.
2
Association Between Early Low-Dose Hydrocortisone Therapy in Extremely Preterm Neonates and Neurodevelopmental Outcomes at 2 Years of Age.极早产儿生后早期接受低剂量氢化可的松治疗与 2 岁时神经发育结局的关系。
JAMA. 2017 Apr 4;317(13):1329-1337. doi: 10.1001/jama.2017.2692.
3
Open-label glucocorticoids modulate dexamethasone trial results in preterm infants.开放性标签糖皮质激素调节早产儿地塞米松试验结果。
Pediatrics. 2010 Oct;126(4):e954-64. doi: 10.1542/peds.2010-0597. Epub 2010 Sep 13.
4
Postnatal hydrocortisone for preventing or treating bronchopulmonary dysplasia in preterm infants: a systematic review.新生儿氢化可的松预防或治疗早产儿支气管肺发育不良的系统评价。
Neonatology. 2010;98(2):111-7. doi: 10.1159/000279992. Epub 2010 Feb 12.
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