血管生成素-2降低作为多囊卵巢综合征中克罗米芬抵抗的预测生物标志物
Reduced Angiopoietin-2 as a Predictive Biomarker for Clomiphene Citrate Resistance in Polycystic Ovary Syndrome.
作者信息
Rajendiran Luxmipratha, Nandeesha Hanumanthappa, Chitra Thyagaraju
机构信息
Department of Biochemistry, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, India.
Department of Obstetrics and Gynecology, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, India.
出版信息
J Hum Reprod Sci. 2021 Apr-Jun;14(2):144-148. doi: 10.4103/jhrs.jhrs_179_20. Epub 2021 Jun 28.
BACKGROUND
Even though angiopoeitin-2 and interleukin (IL)-23 are known to be altered in polycystic ovary syndrome (PCOS), their association with clomiphene citrate (CC) resistance has not been studied.
AIM
The objective of the study was to investigate whether angiopoietin-2 levels are associated with inflammation and CC resistance in PCOS.
SETTINGS AND DESIGN
This study was conducted in a tertiary care hospital.
MATERIALS AND METHODS
Eighty-one women diagnosed with PCOS and on treatment with CC were enrolled in the study. Angiopoeitin-2 and IL -23 were analyzed in all the subjects.
RESULTS
Angiopoietin-2 was significantly reduced ( = 0.018), and body mass index (BMI) ( = 0.049) and duration of infertility (0.006) were significantly increased in PCOS women with CC resistance compared to those who are sensitive to CC. In CC resistant PCOS, IL-23 predicts reduction in angiopoietin-2 levels ( = 0.010). Among angiopoietin-2, IL-23, BMI, and duration of infertility, we found that angiopoeitn-2 ( = 0.020) and duration of infertility (0.036) can predict resistance to CC therapy among PCOS subjects.
CONCLUSION
We conclude that reduced angiopoietin-2 levels predict CC resistance in women with PCOS.
背景
尽管已知血管生成素-2和白细胞介素（IL）-23在多囊卵巢综合征（PCOS）中发生改变，但它们与枸橼酸氯米芬（CC）抵抗的关系尚未得到研究。
目的
本研究的目的是调查血管生成素-2水平是否与PCOS中的炎症和CC抵抗相关。
设置与设计
本研究在一家三级护理医院进行。
材料与方法
81名被诊断为PCOS并接受CC治疗的女性纳入本研究。对所有受试者分析血管生成素-2和IL-23。
结果
与对CC敏感的PCOS女性相比，CC抵抗的PCOS女性中血管生成素-2显著降低（P = 0.018），体重指数（BMI）（P = 0.049）和不孕持续时间（P = 0.006）显著增加。在CC抵抗的PCOS中，IL-23可预测血管生成素-2水平降低（P = 0.010）。在血管生成素-2、IL-23、BMI和不孕持续时间中，我们发现血管生成素-2（P = 0.020）和不孕持续时间（P = 0.036）可预测PCOS受试者对CC治疗的抵抗。
结论
我们得出结论，血管生成素-2水平降低可预测PCOS女性对CC的抵抗。
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