血管生成素-2：一种具有双重功能的细胞因子，既能促进血管生成，又能参与炎症反应。
Angiopoietin-2: a multifaceted cytokine that functions in both angiogenesis and inflammation.
机构信息
Department of Pathology, Laboratory of Immunology and Vascular Biology, Stanford University School of Medicine, Stanford, California.
Edinger Institute/Institute of Neurology, Frankfurt University Medical School, Frankfurt, Germany.
出版信息
Ann N Y Acad Sci. 2015 Jul;1347:45-51. doi: 10.1111/nyas.12726. Epub 2015 Mar 13.
Angiogenesis and inflammation are two highly linked processes. In the last decade, several factors with dual function in both of these major pathways have been identified. This review focuses on angiopoietin-2 (Ang-2), an important proangiogenic factor that has more recently been implicated in mediating inflammatory processes as well. Ang-2 is upregulated in multiple inflammatory diseases and has been implicated in the direct control of inflammation-related signaling pathways. As a consequence of its multiple roles, designs for therapeutic targeting of Ang-2 should consider the dual function of this factor in regulating angiogenesis and inflammation.
血管生成和炎症是两个高度相关的过程。在过去的十年中，已经确定了几种在这两个主要途径中具有双重功能的因子。本综述重点介绍血管生成素-2 (Ang-2)，它是一种重要的促血管生成因子，最近也被认为介导炎症过程。Ang-2 在多种炎症性疾病中上调，并被牵连直接控制炎症相关信号通路。由于其多种作用，针对 Ang-2 的治疗靶向设计应考虑该因子在调节血管生成和炎症中的双重功能。
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