Omage Sylvia Oghogho, Orhue Noghayin E Jerry, Omage Kingsley
Department of Biochemistry, Faculty of Life Sciences, University of Benin, Benin City, Edo State 300213, Nigeria.
Department of Biochemistry, College of Health Sciences, School of Basic Medical Sciences, Igbinedion University Okada, Benin City, Edo State 302110, Nigeria.
Prev Nutr Food Sci. 2021 Jun 30;26(2):177-185. doi: 10.3746/pnf.2021.26.2.177.
, better known as 'pepperfruit', is a medicinal plant consumed in West Africa. possesses strong antioxidant properties and contains uvariopsine, an alkaloid which improves bile secretion and liver function. In the present study, the ethanolic extract of fruits was tested for its ability to alleviate pathophysiological conditions bordering on oxidative stress, including protein and lipid dyshomeostasis, inflammation, and hepatic and glomerular injury. Male albino Wistar rats were administered carbon tetrachloride twice a week for two weeks, and the ethanolic extract of fruits was administered from days 8∼14. The serum, liver, and kidneys of the rats were then subjected to biochemical assays and imaging. The extract restored the activities of liver marker enzymes in serum and the concentrations of lipids and proteins in both circulation and the liver to normal. The extract also restored the activities of antioxidant enzymes in liver and kidneys, and the concentrations of urea and creatinine in the blood. The extract also repaired the altered structures of the liver and kidney. Overall, elicited strong medicinal effects in rats. This study showed that the fruits of contain substances that could be extracted or synthesized for use in drugs for the treatment of liver and kidney disease.
，更为人所知的名称是“胡椒果”，是一种在西非食用的药用植物。它具有很强的抗氧化特性，并且含有乌瓦瑞辛，一种能改善胆汁分泌和肝功能的生物碱。在本研究中，对该植物果实的乙醇提取物减轻与氧化应激相关的病理生理状况的能力进行了测试，这些状况包括蛋白质和脂质稳态失调、炎症以及肝脏和肾小球损伤。雄性白化Wistar大鼠每周两次给予四氯化碳，持续两周，从第8天至第14天给予该植物果实的乙醇提取物。然后对大鼠的血清、肝脏和肾脏进行生化分析和成像。提取物使血清中肝脏标志物酶的活性以及循环系统和肝脏中脂质和蛋白质的浓度恢复正常。提取物还恢复了肝脏和肾脏中抗氧化酶的活性以及血液中尿素和肌酐的浓度。提取物还修复了肝脏和肾脏改变的结构。总体而言，该植物在大鼠中产生了强大的药用效果。这项研究表明，该植物的果实含有可提取或合成用于治疗肝脏和肾脏疾病药物的物质。
