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利伐沙班治疗心肌病和肝硬化时左心室血栓复发形成

Recurrent Left Ventricular Thrombus Formation on Rivaroxaban Therapy in Cardiomyopathy and Liver Cirrhosis.

作者信息

Ghani Usman, Wiley Karlo A, Singhal Raman, Sanina Cristina

机构信息

Department of Internal Medicine, Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, New York.

College of Agriculture and Life Science, Cornell University, Ithaca, New York.

出版信息

JACC Case Rep. 2020 Aug 19;2(10):1501-1504. doi: 10.1016/j.jaccas.2020.05.094. eCollection 2020 Aug.

DOI:10.1016/j.jaccas.2020.05.094
PMID:34317005
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8302174/
Abstract

Left ventricular (LV) thrombus in patients with reduced LV systolic function carries significant thromboembolic risk. Direct oral anticoagulants are an attractive alternative to warfarin for LV thrombus management. However, there are not enough data regarding the safety and efficacy of direct oral anticoagulants for the treatment of LV thrombus. ().

摘要

左心室收缩功能降低的患者发生左心室（LV）血栓会带来显著的血栓栓塞风险。对于左心室血栓的管理，直接口服抗凝剂是华法林的一个有吸引力的替代选择。然而，关于直接口服抗凝剂治疗左心室血栓的安全性和有效性的数据还不够充分。（）

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9153/8302174/a0a10b45107f/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9153/8302174/775ef2d2ced6/fx1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9153/8302174/6070cad29b61/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9153/8302174/3aa2c338b7ac/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9153/8302174/a0a10b45107f/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9153/8302174/775ef2d2ced6/fx1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9153/8302174/6070cad29b61/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9153/8302174/3aa2c338b7ac/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9153/8302174/a0a10b45107f/gr3.jpg

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本文引用的文献

1
Direct Oral Anticoagulants for the Treatment of Left Ventricular Thrombus-A New Indication? A Meta-summary of Case Reports.直接口服抗凝剂治疗左心室血栓形成的新适应证？病例报告的荟萃分析。
J Cardiovasc Pharmacol. 2020 Jun;75(6):530-534. doi: 10.1097/FJC.0000000000000826.
2
Direct Oral Anticoagulants in Cirrhotic Patients: Current Evidence and Clinical Observations.直接口服抗凝剂在肝硬化患者中的应用：当前证据和临床观察。
Can J Gastroenterol Hepatol. 2019 Jan 8;2019:4383269. doi: 10.1155/2019/4383269. eCollection 2019.
3
The role of rivaroxaban in left ventricular thrombi.
利伐沙班在左心室血栓形成中的作用。
Anatol J Cardiol. 2019 Jan;21(1):47-50. doi: 10.14744/AnatolJCardiol.2018.48313.
4
Hypercoagulability in End-stage Liver Disease: Review of Epidemiology, Etiology, and Management.终末期肝病的高凝状态：流行病学、病因及管理综述
Transplant Direct. 2018 Oct 26;4(11):e403. doi: 10.1097/TXD.0000000000000843. eCollection 2018 Nov.
5
Anticoagulant therapy in patients with liver cirrhosis and portal vein thrombosis: insights for the clinician.肝硬化合并门静脉血栓形成患者的抗凝治疗：临床医生须知
Therap Adv Gastroenterol. 2018 Sep 6;11:1756284818793561. doi: 10.1177/1756284818793561. eCollection 2018.
6
Incidence of bleeding in patients with atrial fibrillation and advanced liver fibrosis on treatment with vitamin K or non-vitamin K antagonist oral anticoagulants.维生素 K 或非维生素 K 拮抗剂口服抗凝剂治疗伴晚期肝纤维化的心房颤动患者的出血发生率。
Int J Cardiol. 2018 Aug 1;264:58-63. doi: 10.1016/j.ijcard.2018.01.097.
7
Off label use of direct oral anticoagulants for left ventricular thrombus. Is it appropriate?直接口服抗凝剂用于左心室血栓的非适应证用药。是否合适？
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8
ASPECTS (Alberta Stroke Program Early CT Score) Measurement Using Hounsfield Unit Values When Selecting Patients for Stroke Thrombectomy.在为卒中取栓术选择患者时，使用亨氏单位值进行ASPECTS（阿尔伯塔卒中项目早期CT评分）测量。
Stroke. 2017 Jun;48(6):1574-1579. doi: 10.1161/STROKEAHA.117.016745. Epub 2017 May 9.
9
Differential in vitro inhibition of thrombin generation by anticoagulant drugs in plasma from patients with cirrhosis.肝硬化患者血浆中抗凝药物对凝血酶生成的体外抑制差异
PLoS One. 2014 Feb 4;9(2):e88390. doi: 10.1371/journal.pone.0088390. eCollection 2014.