纳洛沙酮对条件性味觉厌恶范式中吗啡 - 乙醇相互作用的影响。

Effects of naloxazone on morphine-ethanol interaction in the conditioned taste aversion paradigm.

作者信息

Ng Cheong Ton J M, Amit Z

机构信息

Dept. of Psychology, Concordia University, Montreal, Que., Canada.

出版信息

Neurosci Lett. 1987 Oct 29;81(3):335-8. doi: 10.1016/0304-3940(87)90406-x.

DOI:10.1016/0304-3940(87)90406-x

PMID:3431748

Abstract

The effects of naloxazone on the interaction between alcohol and morphine were examined in the conditioned taste aversion paradigm (CTA). Naloxazone injected 4.5 h before the pre-exposure drug significantly attenuated the pre-exposure effect of morphine on ethanol CTA as well as the effect of ethanol on morphine CTA. The results are discussed in terms of possible mechanisms of opiate-alcohol interaction.

摘要

在条件性味觉厌恶范式（CTA）中研究了纳洛沙酮对酒精与吗啡相互作用的影响。在预先接触药物前4.5小时注射纳洛沙酮，可显著减弱吗啡对乙醇CTA的预先接触效应以及乙醇对吗啡CTA的效应。根据阿片类药物与酒精相互作用的可能机制对结果进行了讨论。