Puhakka H J
Department of Otolaryngology, University Central Hospital, Turku, Finland.
ORL J Otorhinolaryngol Relat Spec. 1987;49(6):321-6. doi: 10.1159/000275958.
From 1975 through 1984 at the Department of Otolaryngology, Turku University Central Hospital, a total of 88 patients with esophageal ulceration due to oral medications were diagnosed endoscopically. The frequency of ulcerations increased until 1980 (14 cases) and was then followed by a decline. There were 24 patients (27.3%) under 20 years of age and 67 patients (76.1%) under 40 years of age, the mean age being 30 years 5 months. Emepronium bromide was the cause of esophageal injury in 24 patients (28.9%), doxycycline in 22 patients (26.5%) and analgetics in 11 patients (13.3%). There were three serious complications in the present series: an esophageal perforation due to doxycycline, an acute mediastinitis and a pericarditis due to emepronium bromide. In this material there was only 1 patient needing dilatation because of stricture formation.
1975年至1984年期间，在图尔库大学中心医院耳鼻喉科，共有88例因口服药物导致食管溃疡的患者经内镜诊断。溃疡发生率在1980年（14例）之前呈上升趋势，之后开始下降。年龄在20岁以下的患者有24例（27.3%），40岁以下的患者有67例（76.1%），平均年龄为30岁5个月。24例（28.9%）患者的食管损伤由溴美喷铵引起，22例（26.5%）由强力霉素引起，11例（13.3%）由镇痛药引起。本系列中有3例严重并发症：1例因强力霉素导致食管穿孔，1例因溴美喷铵引起急性纵隔炎，1例因溴美喷铵引起心包炎。在该病例资料中，只有1例患者因狭窄形成需要进行扩张治疗。
