强力霉素治疗引发的食管溃疡
Esophageal ulceration complicating doxycycline therapy.
作者信息
Al-Mofarreh Mohammad A, Al Mofleh Ibrahim A
机构信息
Physician & Gastroenterology Poly Clinic, College of Medicine, King Saud University, Riyadh, Saudi Arabia.
出版信息
World J Gastroenterol. 2003 Mar;9(3):609-11. doi: 10.3748/wjg.v9.i3.609.
AIM
To report present state of iatrogenic drug-induced esophageal injury (DIEI) induced by medications in a private clinic.
METHODS
Iatrogenic drug-induced esophageal injury (DIEI) induced by medications has been more frequently reported. In a private clinic we encountered 36 cases of esophageal ulcerations complicating doxycycline therapy in a mainly younger Saudi population (median age 29 years).
RESULTS
The most frequent presenting symptoms were odynophagia, retrosternal burning pain and dysphagia (94 %, 75 % and 56 %, respectively). The diagnosis was according to medical history and confirmed by endoscopy in all patients. Beside withdrawal of doxycycline, when feasible, all patients were treated with a proton-pump inhibitor (PPI) and a prokinetic. Thirty patients who reported to the clinic after treatment were improved within 1-7 (median 1.7) days.
CONCLUSION
Esophageal ulceration has to be suspected in younger patients with odynophagia, retrosternal burning pain and/or dysphagia during the treatment with doxycycline.
目的
报告一家私人诊所中药物引起的医源性药物性食管损伤（DIEI）的现状。
方法
药物引起的医源性药物性食管损伤（DIEI）的报道越来越多。在一家私人诊所，我们遇到36例在主要为年轻沙特人群（中位年龄29岁）中多西环素治疗并发食管溃疡的病例。
结果
最常见的症状是吞咽痛、胸骨后灼痛和吞咽困难（分别为94%、75%和56%）。根据病史进行诊断，并在所有患者中通过内镜检查得到证实。除了停用多西环素（可行时），所有患者均接受质子泵抑制剂（PPI）和促动力药治疗。30例治疗后到诊所就诊的患者在1 - 7天（中位时间1.7天）内病情好转。
结论
在多西环素治疗期间，出现吞咽痛、胸骨后灼痛和/或吞咽困难的年轻患者必须怀疑有食管溃疡。
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