Department of Pathology, M.L.N. Medical College, Allahabad, India.
Departement of E.N.T., M.L.N. Medical College, Allahabad, India.
Asian Pac J Cancer Prev. 2021 Jul 1;22(7):2273-2278. doi: 10.31557/APJCP.2021.22.7.2273.
Oral cancer accounts for 50-70% of total cancer mortality. VIA screening has drastically changed the morbidity and mortality related to cervical cancer. In present study, we assessed the role of 5% Acetic Acid as a vital stain in oral mucosa of chronic tobacco chewers, to know if it can help in early diagnosis and improved prognosis of oral malignancies and to assess the sensitivity and specificity of VIA and exfoliative cytology for screening of Oral premalignant and malignant lesions in high risk population with limited health care infrastructure.
This was an outpatient department based prospective study done in a tertiary hospital over a period of two years. 150 cases with a history of chronic tobacco use were evaluated. Visual inspection (VI) followed by VIA using 5% Acetic acid was done. Oral scrapes were taken for cytological examination followed by biopsy for histopathological evaluation, wherever possible.
Sensitivity, specificity, PPV, NPV and accuracy of VIA and Exfoliative cytology was 71%, 65%, 83%, 48%, 69% and 98%, 65%, 89%, 92%, 88% respectively keeping histology as gold standard.
Acetic acid along with exfoliative cytology can be used as simple, cost effective and convenient methods for mass screening of OPMDs and OSCC in high risk population where biopsy is not possible.
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口腔癌占癌症总死亡率的 50-70%。阴道镜检查极大地改变了与宫颈癌相关的发病率和死亡率。在本研究中，我们评估了 5%醋酸作为慢性烟草咀嚼者口腔黏膜重要染色剂的作用，以了解它是否有助于早期诊断和改善口腔恶性肿瘤的预后，并评估 VIA 和细胞学刮片在高风险人群中的筛查作用，这些人群的口腔癌前病变和恶性病变发病率高，但医疗基础设施有限。
这是一项在一家三级医院进行的为期两年的门诊基础前瞻性研究。共评估了 150 例有慢性烟草使用史的病例。进行了目视检查（VI），然后使用 5%醋酸进行 VIA。对口腔刮片进行细胞学检查，然后在可能的情况下进行活检进行组织病理学评估。
以组织学为金标准，VIA 和细胞学刮片的敏感性、特异性、PPV、NPV 和准确性分别为 71%、65%、83%、48%和 69%和 98%、65%、89%、92%、88%。
醋酸与细胞学刮片联合使用，可以作为一种简单、经济有效的方法，用于高风险人群中口腔癌前病变和口腔鳞状细胞癌的大规模筛查，在这些人群中，活检是不可行的。
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