Bhalang Kanokporn, Suesuwan Anocha, Dhanuthai Kittipong, Sannikorn Phakdee, Luangjarmekorn Lakana, Swasdison Somporn
Department of Oral Medicine, Chulalongkorn University, Bangkok, Thailand.
Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2008 Sep;106(3):371-6. doi: 10.1016/j.tripleo.2008.01.017. Epub 2008 Jun 11.
Oral cancer is the fourth most common cancer in males and the seventh most common cancer in females in Thailand. The survival rates and quality of life of oral cancer patients will significantly be improved if they receive treatment for lesions that are less advanced or premalignant. Early diagnosis is therefore of paramount importance. A number of techniques have been developed to supplement clinical examination for oral malignancy. One interesting screening method is the application of 3% to 5% acetic acid, which has been used for cervical cancer screening.
The primary objective of this study was to assess the sensitivity, specificity, and accuracy of using vinegar (5% acetic acid) for the examination of oral cancer. The secondary objective was to investigate the association between clinical examination using acetic acid and expression of the tumor marker, p53.
The study included 30 participants suspected of having oral squamous cell carcinoma. Five percent acetic acid was applied to the lesions, followed by incisional biopsy. The specimens were microscopically examined for pathological diagnosis and p53 immunohistochemical investigation.
The sensitivity, specificity, and accuracy of using acetic acid for oral cancer examination were 83.33%, 84.21%, and 83.64%, respectively. There was a statistically significant association between clinical examination using acetic acid and expression of p53 protein (P = .000).
The results of this study suggest that 5% acetic acid has high sensitivity, specificity, and accuracy in detecting oral squamous cell carcinoma and might be used as an adjunct for oral cancer examination.
在泰国，口腔癌是男性中第四大常见癌症，女性中第七大常见癌症。如果口腔癌患者能够对较早期或癌前病变进行治疗，其生存率和生活质量将得到显著改善。因此，早期诊断至关重要。已经开发了多种技术来辅助口腔恶性肿瘤的临床检查。一种有趣的筛查方法是应用3%至5%的醋酸，该方法已用于宫颈癌筛查。
本研究的主要目的是评估使用醋（5%醋酸）检查口腔癌的敏感性、特异性和准确性。次要目的是研究使用醋酸进行临床检查与肿瘤标志物p53表达之间的关联。
该研究纳入了30名疑似患有口腔鳞状细胞癌的参与者。将5%的醋酸应用于病变部位，随后进行切取活检。对标本进行显微镜检查以进行病理诊断和p53免疫组织化学研究。
使用醋酸检查口腔癌的敏感性、特异性和准确性分别为83.33%、84.21%和83.64%。使用醋酸进行临床检查与p53蛋白表达之间存在统计学上的显著关联（P = .000）。
本研究结果表明，5%醋酸在检测口腔鳞状细胞癌方面具有较高的敏感性、特异性和准确性，可作为口腔癌检查的辅助手段。
