成人神经系统疾病的颅神经无创神经调节：一项范围综述的方案

Cranial Nerve Noninvasive Neuromodulation in Adults With Neurological Conditions: Protocol for a Scoping Review.

作者信息

Boughen Keaton, Neil Tyler, Dullemond Shayan, Lutowicz Kevin, Bilgasem Ahmed, Hastings Tyler, Brooks Dina, Vaughan-Graham Julie

机构信息

Physiotherapy Program, School of Rehabilitation Science, Faculty of Health Sciences, McMaster University, Hamilton, ON, Canada.

Department of Physical Therapy, Faculty of Medicine, University of Toronto, Toronto, ON, Canada.

出版信息

JMIR Res Protoc. 2021 Jul 28;10(7):e29965. doi: 10.2196/29965.

DOI:10.2196/29965

PMID:34319251

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8367107/

Abstract

BACKGROUND

Cranial nerve noninvasive neuromodulation (CN-NINM) via translingual nerve stimulation (TLNS) is a promising new intervention combined with neurological rehabilitation to improve outcomes for persons with neurological conditions. A portable neuromodulation stimulation (PoNS) device rests on the tongue and stimulates cranial nerves V and VII (trigeminal and facial nerves, respectively). Emerging evidence suggests that CN-NINM using the PoNS device, combined with targeted physical therapy, improves balance and gait outcomes but has not yet been comprehensively reviewed.

OBJECTIVE

This review will describe CN-NINM via TLNS and its applications, effects, and implications for rehabilitation science in adult populations with neurological conditions. We will identify how CN-NINM via TLNS is currently being incorporated into neurological rehabilitation and identify gaps in evidence with respect to this novel technology.

METHODS

Joanna Briggs Institute methodology will be used to conduct this scoping review. Electronic databases MEDLINE, AMED, CINAHL, Embase, and Web of Science will be searched, as well as gray literature databases ProQuest, DuckDuckGo, and Google. Studies published in English and French between 2000 and 2021 will be included. Two reviewers will independently screen all titles and abstracts and full-text papers that meet the inclusion criteria. Data will be extracted and collated in a table to synthesize the results. Extracted data will be reported in a comprehensive summary.

RESULTS

The final manuscript is intended for submission to an indexed journal in September 2021.

CONCLUSIONS

This scoping review will be the first, to our knowledge, to address the current evidence on CN-NINM. The results will inform the use of CN-NINM in neurological rehabilitation and the development of recommendations for future research.

TRIAL REGISTRATION

Open Science Framework 10.17605/OSF.IO/XZQFM; https://osf.io/xzqfm.

INTERNATIONAL REGISTERED REPORT IDENTIFIER (IRRID): PRR1-10.2196/29965.

摘要

背景

经舌神经刺激（TLNS）进行的颅神经无创神经调节（CN-NINM）是一种很有前景的新干预措施，可与神经康复相结合，改善神经疾病患者的治疗效果。一种便携式神经调节刺激（PoNS）装置放置在舌头上，刺激颅神经V和VII（分别为三叉神经和面神经）。新出现的证据表明，使用PoNS装置进行的CN-NINM与有针对性的物理治疗相结合，可改善平衡和步态结果，但尚未得到全面综述。

目的

本综述将描述通过TLNS进行的CN-NINM及其在患有神经疾病的成年人群中的应用、效果和对康复科学的意义。我们将确定目前通过TLNS进行的CN-NINM是如何纳入神经康复的，并确定关于这项新技术的证据空白。

方法

将使用乔安娜·布里格斯研究所的方法进行这项范围综述。将检索电子数据库MEDLINE、AMED、CINAHL、Embase和科学网，以及灰色文献数据库ProQuest、DuckDuckGo和谷歌。将纳入2000年至2021年期间以英文和法文发表的研究。两名评审员将独立筛选所有符合纳入标准的标题、摘要和全文论文。数据将被提取并整理成表格以综合结果。提取的数据将在全面总结中报告。