HealthTech Connex, Surrey, British Columbia, Canada.
Pavlov Institute of Physiology, Russian Academy of Science, Sankt Petersburg, Russia.
J Neuroeng Rehabil. 2019 May 27;16(1):60. doi: 10.1186/s12984-019-0538-4.
Despite growing evidence of a critical link between neuromodulation technologies and neuroplastic recovery, the underlying mechanisms of these technologies remain elusive.
To investigate physiological evidence of central nervous system (CNS) changes in humans during translingual neurostimulation (TLNS).
We used high-density electroencephalography (EEG) to measure changes in resting brain activity before, during, and after high frequency (HF) and low frequency (LF) TLNS.
Wavelet power analysis around Cz and microstate analysis revealed significant changes after 20 min of stimulation compared to baseline. A secondary effect of exposure order was also identified, indicating a differential neuromodulatory influence of HF TLNS relative to LF TLNS on alpha and theta signal power.
These results further our understanding of the effects of TLNS on underlying resting brain activity, which in the long-term may contribute to the critical link between clinical effect and changes in brain activity.
尽管越来越多的证据表明神经调节技术与神经可塑性恢复之间存在着关键联系，但这些技术的潜在机制仍难以捉摸。
研究在经舌神经刺激（TLNS）过程中，人类中枢神经系统（CNS）变化的生理证据。
我们使用高密度脑电图（EEG）测量高频（HF）和低频（LF）TLNS 前后静息脑活动的变化。
在 Cz 周围的小波功率分析和微状态分析显示，与基线相比，刺激 20 分钟后有明显变化。还确定了暴露顺序的次要影响，表明 HF TLNS 对阿尔法和 theta 信号功率的神经调节影响相对于 LF TLNS 存在差异。
这些结果进一步了解了 TLNS 对基础静息脑活动的影响，从长远来看，这可能有助于建立临床疗效与脑活动变化之间的关键联系。
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