Department of Psychiatry, Marmara University Pendik Training and Research Hospital, Istanbul, Turkey.
Department of Child and Adolescent Psychiatry, Maltepe University Medical School, Istanbul, Turkey.
Nord J Psychiatry. 2021 Nov;75(8):624-632. doi: 10.1080/08039488.2021.1919201. Epub 2021 Jul 28.
As non-specific markers of immune dysregulation, neutrophil-lymphocyte and platelet-lymphocyte ratios (NLR and PLR) have been consistently shown to be increased in major neuropsychiatric disorders. Although this increase seems to be trans-diagnostic, the extent to which its magnitude differs between disorders remains largely unclear.
The aim of this study was to directly compare the severity of inflammation (as reflected by NLR and PLR) between schizophrenia (Sch), bipolar mania (BD-M), bipolar depression (BD-D), major depressive disorder (MDD) and obsessive compulsive disorder (OCD).
NLR and PLR were obtained for a total of 417 subjects (91 Sch, 70 BD-D, 37 BD-M, 93 MDD, 37 OCD, and 95 controls) and analyzed for group differences.
Sch, BD-M, BD-D and MDD presented with significantly higher NLR compared with both OCD and HC. NLR in BD-M was significantly higher than all the remaining groups, whereas Sch, BD-D and MDD presented with comparably elevated NLR. Moreover, BD-M, Sch and MDD had significantly higher PLR compared with HC.
These results suggest that the underlying inflammation may be most severe in BD-M, followed by Sch, BD-D and MDD. On the other hand, inflammation may be of negligible intensity in OCD, or at least undetectable by means of NLR or PLR.
中性粒细胞与淋巴细胞比值（NLR）和血小板与淋巴细胞比值（PLR）作为免疫失调的非特异性标志物，在多种主要神经精神疾病中一直表现出升高。尽管这种升高似乎具有跨诊断的特征，但不同疾病之间其程度的差异程度在很大程度上仍不清楚。
本研究旨在直接比较精神分裂症（Sch）、双相躁狂（BD-M）、双相抑郁（BD-D）、重性抑郁障碍（MDD）和强迫症（OCD）之间炎症严重程度（反映在 NLR 和 PLR 上）。
共纳入 417 名受试者（91 名 Sch 患者、70 名 BD-D 患者、37 名 BD-M 患者、93 名 MDD 患者、37 名 OCD 患者和 95 名健康对照者），并对 NLR 和 PLR 进行组间差异分析。
Sch、BD-M、BD-D 和 MDD 的 NLR 明显高于 OCD 和 HC。BD-M 的 NLR 明显高于所有其他组，而 Sch、BD-D 和 MDD 的 NLR 则相当高。此外，BD-M、Sch 和 MDD 的 PLR 明显高于 HC。
这些结果表明，BD-M 中潜在的炎症可能最为严重，其次是 Sch、BD-D 和 MDD。另一方面，炎症在 OCD 中可能强度微不足道，或者至少不能通过 NLR 或 PLR 检测到。
