Deng Zi-Qi, Si Xiao-Chen, Song Jia-Bin, Li Jin-Yao, Sun Lu, Dang Xue, Zhao Min, Feng Yan-Chen, Liu Fei-Xiang
Department of Neuropsychiatric Psychology, Hospital of Encephalopathy, The First Affiliated Hospital of Traditional Henan University of Chinese Medicine, Zhengzhou, China.
Institute of Management and Science University, Henan University of Chinese Medicine, Zhengzhou, China.
Front Neurosci. 2025 May 9;19:1544311. doi: 10.3389/fnins.2025.1544311. eCollection 2025.
Mania is a mind disorder with heightened emotions, etc. Amphetamine (AMPH), a drug with central nervous system excitatory effects, can disrupt neurotransmitter release and metabolism, causing mania. AMPH-induced animal models of mania show increased risk and reward-seeking behaviors and excessive locomotion like mania patients, verifiable by tests like Elevated Plus Maze (EPM). It also impacts neurotransmitter balance in different brain regions, aligning with the imbalance in mania patients. Multiple signaling pathways including extracellular regulated protein kinases and others are involved, and their altered activities link to mania symptoms. In the AMPH-induced mania model, regions like the frontal cortex have increased oxidative stress and inflammatory response. Moreover, AMPH changes neurotrophin levels, potentially causing neuronal damage and cognitive impairment. In summary, the AMPH-induced mania animal model is crucial for studying mania's pathogenesis. However, further in-depth studies on neurotransmitter regulation, signaling pathway intervention, and neurotrophic factors are needed to develop more effective and personalized treatment plans.
躁狂症是一种伴有情绪高涨等症状的精神障碍。苯丙胺（AMPH）是一种具有中枢神经系统兴奋作用的药物，可干扰神经递质的释放和代谢，从而引发躁狂症。AMPH诱导的躁狂症动物模型表现出与躁狂症患者相似的增加的风险和奖赏寻求行为以及过度活动，这可通过高架十字迷宫（EPM）等测试得到验证。它还会影响不同脑区的神经递质平衡，这与躁狂症患者的失衡情况相符。包括细胞外调节蛋白激酶等在内的多种信号通路都参与其中，它们活动的改变与躁狂症症状相关。在AMPH诱导的躁狂症模型中，额叶皮质等区域的氧化应激和炎症反应会增加。此外，AMPH会改变神经营养因子水平，可能导致神经元损伤和认知障碍。总之，AMPH诱导的躁狂症动物模型对于研究躁狂症的发病机制至关重要。然而，需要对神经递质调节、信号通路干预和神经营养因子进行进一步深入研究，以制定更有效和个性化的治疗方案。
