Bolhuis G K, Smallenbroek A J, Lerk C F
J Pharm Sci. 1981 Dec;70(12):1328-30. doi: 10.1002/jps.2600701210.
The effect of magnesium stearate on the disintegration of tablets was studied. Three different preblends, containing a slightly or a strongly swelling disintegrant, were mixed before compression with magnesium stearate for different time periods. The results show that a strongly swelling disintegrant, such as sodium starch glycolate in contrast to potato starch, can reduce the deteriorating effect of hydrophobic lubricants on tablet disintegration. However, the interaction between magnesium stearate and potato starch or sodium starch glycolate and the resulting differences in disintegration characteristics can be masked by the use of disks in the USP disintegration apparatus.
研究了硬脂酸镁对片剂崩解的影响。三种不同的预混物，分别含有轻度或强烈膨胀的崩解剂，在压片前与硬脂酸镁混合不同的时间段。结果表明，与马铃薯淀粉相比，强烈膨胀的崩解剂，如羟丙基淀粉钠，可以降低疏水性润滑剂对片剂崩解的恶化作用。然而，硬脂酸镁与马铃薯淀粉或羟丙基淀粉钠之间的相互作用以及由此产生的崩解特性差异，可通过美国药典崩解仪中使用的圆盘而被掩盖。
