Department of Immunology, Institute for Biological Research "Siniša Stanković" - National Institute of Republic of Serbia, University of Belgrade, 11000 Belgrade, Serbia.
Department of Immunology, Institute for Biological Research "Siniša Stanković" - National Institute of Republic of Serbia, University of Belgrade, 11000 Belgrade, Serbia.
Immunol Lett. 2021 Oct;238:40-46. doi: 10.1016/j.imlet.2021.07.008. Epub 2021 Jul 25.
Sepsis is a life-threatening condition characterized by an acute cytokine storm followed by prolonged dysfunction of the immune system in the survivors. Post-septic lymphopenia and functional deficits of the remaining immune cells lead to increased susceptibility to secondary infections and other morbid conditions causing late death in the patients. This state of post-septic immunoparalysis may also influence disorders stemming from inappropriate or overactive immune responses, such as autoimmune and immunoinflammatory diseases, including multiple sclerosis. In addition, ongoing autoimmunity likely influences the susceptibility to and outcome of sepsis. This review article addresses the bidirectional relationship between sepsis and multiple sclerosis, with a focus on the immunologic mechanisms of the interaction and potential directions for future studies.
脓毒症是一种危及生命的病症，其特征是急性细胞因子风暴，随后幸存者的免疫系统长期功能障碍。脓毒症后淋巴细胞减少和残留免疫细胞的功能缺陷导致易继发感染和其他病态状况，使患者晚期死亡。这种脓毒症后免疫麻痹状态也可能影响源自不适当或过度免疫反应的疾病，如自身免疫和免疫炎症性疾病，包括多发性硬化症。此外，持续的自身免疫可能影响脓毒症的易感性和结局。这篇综述文章探讨了脓毒症和多发性硬化症之间的双向关系，重点介绍了相互作用的免疫机制以及未来研究的潜在方向。
