Immunology Graduate Program, Baylor College of Medicine, Houston, TX, United States.
Immunology Program of the Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, United States.
Front Immunol. 2020 Dec 23;11:597966. doi: 10.3389/fimmu.2020.597966. eCollection 2020.
Autoimmune diseases and chronic inflammatory disorders are characterized by dysregulated immune responses resulting in excessive and uncontrolled tissue inflammation. Multiple factors including genetic variation, environmental stimuli, and infection are all thought to contribute to continued inflammation and pathology. Current evidence supports the microbiota as one such factor with emerging data linking commensal organisms to the onset and progression of disease. In this review, we will discuss links between the microbiota and specific diseases as well as highlight common pathways that link intestinal microbes with multiple autoimmune and inflammatory diseases.
自身免疫性疾病和慢性炎症性疾病的特征是免疫反应失调，导致过度和失控的组织炎症。多种因素，包括遗传变异、环境刺激和感染，都被认为有助于持续的炎症和病理。目前的证据支持微生物组是其中的一个因素，越来越多的数据将共生生物与疾病的发生和进展联系起来。在这篇综述中，我们将讨论微生物组与特定疾病之间的联系，并强调将肠道微生物与多种自身免疫性和炎症性疾病联系起来的共同途径。
