Ensing K, De Zeeuw R A, Hörnchen U, Schüttler J, Stoeckel H
State University of Groningen, Groningen Centre for Drug Research, The Netherlands.
Pharm Weekbl Sci. 1987 Dec 11;9(6):321-3. doi: 10.1007/BF01956512.
A highly sensitive radioreceptor assay for the anticholinergic atropine was developed and could be applied directly to plasma samples obtained from mini-pigs without any clean-up. Plasma samples were collected during 6 h after atropine was administered intravenously or endobronchially. The endobronchial plasma concentration-time curves were characterized by a very rapid rise of the concentration but with a subsequent much slower decrease than after intravenous administration. This indicates an initially high as well as prolonged uptake from the lungs.
开发了一种用于抗胆碱能药物阿托品的高灵敏度放射受体测定法，该方法可直接应用于从小型猪采集的血浆样本，无需任何净化处理。在静脉内或支气管内给予阿托品后的6小时内采集血浆样本。支气管内血浆浓度-时间曲线的特征是浓度迅速上升，但随后下降速度比静脉给药后慢得多。这表明最初从肺部摄取量高且持续时间长。
