Schüttler J, Hörnchen U, Stoeckel H, Hahn N
Langenbecks Arch Chir. 1987;370(2):119-27. doi: 10.1007/BF01254089.
The present animal study was designed to investigate the pharmacokinetic behavior of epinephrine after endobronchial (e.b.) and intravenous (i.v.) administration and its correlation to pharmacodynamic measurements. We found the effectiveness of e.b.-epinephrine (100 micrograms/kg BW) to be in the same magnitude as i.v.-epinephrine (100 micrograms/kg BW) with only a slight delay in the pharmacodynamic onset of a few seconds. The bioavailability of e.b.-administration of epinephrine was in the range of 80-85%. The therapeutic effect of e.b.-epinephrine (100 micrograms/kg BW) lasted much longer (30 min) when compared to i.v.-epinephrine (10 micrograms/kg BW) where the pharmacodynamic effect was terminated after 3 to 5 min. For the clinical situation of cardiopulmonary resuscitation a dose of 2-3 mg epinephrine in 5-10 ml of physiological saline instilled deeply into the bronchial system should be considered as alternative administration technique with fast onset and good effectiveness.
本动物研究旨在调查肾上腺素经支气管内（e.b.）和静脉内（i.v.）给药后的药代动力学行为及其与药效学测量的相关性。我们发现，支气管内注射肾上腺素（100微克/千克体重）的有效性与静脉注射肾上腺素（100微克/千克体重）相当，只是药效学起效稍有延迟，延迟几秒。支气管内给药肾上腺素的生物利用度在80%至85%之间。与静脉注射肾上腺素（10微克/千克体重）相比，支气管内注射肾上腺素（100微克/千克体重）的治疗效果持续时间长得多（30分钟），静脉注射肾上腺素的药效学作用在3至5分钟后终止。对于心肺复苏的临床情况，应考虑将2至3毫克肾上腺素溶于5至10毫升生理盐水中，深部注入支气管系统，作为起效快且效果良好的替代给药技术。
