School of Exercise Science, Sport and Health, Charles Sturt University, Bathurst, NSW, Australia.
School of Exercise Science, Sport and Health, Charles Sturt University, Bathurst, NSW, Australia.
Cytokine. 2021 Oct;146:155648. doi: 10.1016/j.cyto.2021.155648. Epub 2021 Jul 25.
This study aimed to investigate the effects of 6-weeks of moderate intensity aerobic exercise on markers of inflammation and symptom severity in those undergoing management of a mental health disorder.
Twenty six participants were allocated into two groups, those reporting as apparently healthy (AH, n = 13) or those undergoing the management of a mental health disorder (MI, n = 13). Following a baseline testing and familiarization session, participants commenced the 6-week aerobic training intervention, involving stationary cycling at 65% heart rate reserve for 35 min progressing to 70% for 40 min. Measures of aerobic fitness (VO), anthropometric variables, symptom questionnaires and venous blood were collect pre- and post-intervention. Venous blood was assessed for nod-like receptor pyrin containing-3, interleukin (IL)-6, tumor necrosis factor-alpha (TNF-α), IL-1β, C-reactive protein (CRP) and brain-derived neurotropic factor (BDNF).
There were no baseline differences between groups, however following the intervention the AH demonstrated lower TNF-α (p = 0.049) than the MI group. Within change was observed for the MI group with an increase in VO (p = 0.049) and declines in symptom severity (p = 0.00-0.005). Significant correlations between variables indicated a positive association between body fat, body fat percentage, CRP and symptom severity (p = 0.01-0.04). Conversely, symptom severity and CRP were inversely associated with VO values (p = 0.02-0.04).
Six-weeks of moderate intensity aerobic exercise increases VO and reduces symptom severity in those currently undergoing management of a mental health disorder. Further, there may be a physiological link between aerobic capacity, symptom severity, inflammation and adiposity, however greater exploration is required.
本研究旨在探讨 6 周中等强度有氧运动对接受心理健康障碍管理人群的炎症标志物和症状严重程度的影响。
26 名参与者被分配到两组，一组报告为明显健康（AH，n=13），另一组正在接受心理健康障碍管理（MI，n=13）。在基线测试和熟悉阶段后，参与者开始进行 6 周的有氧运动干预，包括在心率储备的 65%下进行固定自行车运动 35 分钟，然后增加到 70%进行 40 分钟。在干预前后测量有氧适能（VO）、人体测量变量、症状问卷和静脉血。静脉血评估了核样受体含pyrin-3、白细胞介素（IL）-6、肿瘤坏死因子-α（TNF-α）、IL-1β、C 反应蛋白（CRP）和脑源性神经营养因子（BDNF）。
两组在基线时没有差异，但干预后 AH 组的 TNF-α 水平低于 MI 组（p=0.049）。MI 组的变化是 VO 增加（p=0.049），症状严重程度下降（p=0.00-0.005）。变量之间的显著相关性表明，体脂肪、体脂肪百分比、CRP 和症状严重程度之间呈正相关（p=0.01-0.04）。相反，症状严重程度和 CRP 与 VO 值呈负相关（p=0.02-0.04）。
6 周的中等强度有氧运动可增加 VO 并减轻正在接受心理健康障碍管理的人的症状严重程度。此外，有氧能力、症状严重程度、炎症和肥胖之间可能存在生理联系，但需要进一步探索。
