Priestley G C, Ryder M L, Head K W
Res Vet Sci. 1977 Nov;23(3):303-9.
Three experiments involving six sheep were carried out at three different times in the annual wool growth cycle. Forty-eight full-thickness fitted autografts were sampled 2 h, 6 h, 24 h, 48 h, 3, 4, 5, 7, 9, 11, 14, 21 and 28 days after grafting. The histopathology of the grafts is described. Individual variation in 'take' was probably related to the speed with which vascular integrity was reestablished between graft and bed. Delayed acceptance caused the death of pilosebaceous units. In a successful graft, wool follicle regeneration appears to occur in three main ways: (1) an inactive follicle regenerates from the dormant bulb at about seven days, (2) follicles that were active at the time of grafting have first to form a papilla stalk, and such follicles did not become active until 11 days, (3) sometimes one or more outgrowths appeared at higher levels suggesting follicle regeneration by branching. In addition there were a few instances of de novo downgrowth of follicle plugs from the epidermis. Wool growth on the graft therefore arises almost entirely from the reorganisation of preexisting follicles.
在羊毛年度生长周期的三个不同时间点进行了涉及六只绵羊的三项实验。在移植后2小时、6小时、24小时、48小时、3天、4天、5天、7天、9天、11天、14天、21天和28天，对48块全层贴合自体移植组织进行了取样。描述了移植组织的组织病理学情况。移植“成活”的个体差异可能与移植组织和植床之间血管完整性重建的速度有关。延迟接受导致毛囊皮脂腺单位死亡。在成功的移植中，毛囊再生似乎主要通过三种方式发生：（1）一个静止的毛囊在大约七天时从休眠的毛囊球再生，（2）移植时活跃的毛囊首先要形成乳头柄，此类毛囊直到11天才变得活跃，（3）有时在较高水平会出现一个或多个分支，提示通过分支进行毛囊再生。此外，有少数情况下毛囊栓会从表皮重新向下生长。因此，移植组织上的羊毛生长几乎完全源于先前存在的毛囊的重组。
