Dey B P, Blenden D C, Burton G C, Mercer H E, Tsutakawa R K
Res Vet Sci. 1977 Nov;23(3):340-3.
The purpose of these experiments was to determine the effects of prior exposure to antimicrobials on subsequent treatment of artificially induced colibacillosis in pigs. One- to two-week-old piglets were given 10(7) multiple antibiotic resistant Escherichia coli orally. Two groups of the piglets received priming doses at different levels of the antimicrobial preparation, ASP-250 before challenge. The remaining group received no antimicrobial. Piglets ill as a result of the challenge were treated with chloramphenicol of chlortetracycline, or received no treatment. Chloramphenicol was significantly more effective than chlortetracycline in terminating colibacillosis in the primed and unprimed groups. There were fewer deaths and relapse cases in those groups which received chloramphenicol treatment. Results in piglets treated with chlortetracycline were not significantly better than those which received no treatment.
这些实验的目的是确定预先接触抗菌药物对猪人工诱发大肠杆菌病后续治疗的影响。给1至2周龄的仔猪口服10(7)多重耐药性大肠杆菌。两组仔猪在攻毒前接受不同剂量抗菌制剂ASP - 250的预激剂量。其余组未接受抗菌药物。因攻毒而患病的仔猪用氯霉素或金霉素治疗，或不接受治疗。在预激组和未预激组中，氯霉素在终止大肠杆菌病方面明显比金霉素更有效。接受氯霉素治疗的组中死亡和复发病例较少。用金霉素治疗的仔猪结果并不比未接受治疗的仔猪明显更好。
