Guo Chengxian, Hu Biwen, Guo Chengjun, Meng Xiangguang, Kuang Yun, Huang Longjian, Wang Danling, Xu Kangwei, Zhao Yanlin, Yang Guoping, Cai Weimin, Shu Yan
Center of Clinical Pharmacology, The Third Xiangya Hospital, Central South University, Changsha, China.
School of Applied Mathematics, Guangdong University of Technology, Guangzhou, China.
Front Pharmacol. 2021 Jul 12;12:682020. doi: 10.3389/fphar.2021.682020. eCollection 2021.
To elucidate current domestic factors influencing pharmacogenomics (PGx) implementation and its future in China, we conducted a questionnaire survey on PGx applications and testing. A questionnaire-based survey was created on the popular online professional survey platform "Wenjuanxing" (www.wjx.cn) and performed the social media platform WeChat. Among 422 participants, there were physicians (27.7%), pharmacists (31.3%), and researchers (41.0%). We found that less than 50% of physicians were aware of the importance of PGx in drug therapy, while over 50% of pharmacists and researchers recognized the importance. Only 38.5% of physicians, 40.9% of pharmacists, and 55.5% of researchers concurred that PGx analysis could lower the economic burdens for patients. However, most of the responders affirmed that PGx should be effectively implemented in clinical practices. A lack of sector standards, a lack of clinical research, and a lack of guidelines were found to be the major factors for hindering PGx clinical application. Among drugs associated with PGx assays, the most common were warfarin and clopidogrel. Although PGx research has advanced rapidly in recent years in mainland China, the clinical implementation of PGx has a long way to go.
为阐明当前影响中国药物基因组学(PGx)实施情况及其未来发展的国内因素,我们针对PGx的应用和检测开展了一项问卷调查。基于问卷的调查在热门在线专业调查平台“问卷星”(www.wjx.cn)上创建,并在社交媒体平台微信上进行。在422名参与者中,有医生(27.7%)、药剂师(31.3%)和研究人员(41.0%)。我们发现,不到50%的医生意识到PGx在药物治疗中的重要性,而超过50%的药剂师和研究人员认识到其重要性。只有38.5%的医生、40.9%的药剂师和55.5%的研究人员认同PGx分析可以降低患者的经济负担。然而,大多数受访者肯定PGx应在临床实践中有效实施。发现缺乏行业标准、缺乏临床研究以及缺乏指南是阻碍PGx临床应用的主要因素。在与PGx检测相关的药物中,最常见的是华法林和氯吡格雷。尽管近年来中国大陆的PGx研究进展迅速,但PGx的临床实施仍有很长的路要走。