Hallén B, Räf L
Department of Pharmacology, R & D, KabiVitrum AB, Stockholm, Sweden.
Pharmacol Toxicol. 1987 Oct;61(4):242-5. doi: 10.1111/j.1600-0773.1987.tb01811.x.
A substantial proportion of a parenteral dose of emepronium given to dogs is excreted via the gastrointestinal tract by biliary excretion and by excretion through the intestinal mucosa (Hallén et al. 1979). In the present paper the different routes of elimination were further investigated in mouse and man and compared to the dog. The disposition of emepronium-derived radioactivity (14C) in the three species showed that about 45% was excreted via urine and 55% via faeces. The proportion of the faecal excretion of 14C that could be referred to the intestinal route differed between the species and was about 20% in man, 60% in the mouse and most pronounced, 80%, in the dog.
给犬注射的依米普铵经肠胃外给药后，很大一部分是通过胆汁排泄和经肠黏膜排泄，经胃肠道排出体外（哈伦等人，1979年）。在本论文中，对依米普铵在小鼠和人体内的不同消除途径进行了进一步研究，并与犬进行了比较。依米普铵衍生的放射性（14C）在这三个物种中的处置情况表明，约45%通过尿液排出，55%通过粪便排出。14C经粪便排泄中可归因于肠道途径的比例在不同物种间存在差异，在人类中约为20%，在小鼠中为60%，在犬中最为显著，为80%。
