塞洛西布减轻大鼠骨关节炎的进展：一项[具体研究类型]研究。 （你提供的原文中“An and Study”部分信息不完整，我只能按现有内容准确翻译）
Selonsertib Alleviates the Progression of Rat Osteoarthritis: An and Study.
作者信息
Yan Jiyuan, Zhang Yingchi, Sheng Gaohong, Ni Bowei, Xiao Yifan, Wang Shanxi, Wang Tianqi, Ma Yongzhuang, Wang Huaixi, Wu Hua, Tu Chang
机构信息
Department of Orthopedics, Renmin Hospital of Wuhan University, Wuhan, China.
Department of Orthopedics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
出版信息
Front Pharmacol. 2021 Jul 12;12:687033. doi: 10.3389/fphar.2021.687033. eCollection 2021.
Osteoarthritis (OA) is a prevalent degenerative joint disease. Its development is highly associated with inflammatory response and apoptosis in chondrocytes. Selonsertib (Ser), the inhibitor of Apoptosis Signal-regulated kinase-1 (ASK1), has exhibited multiple therapeutic effects in several diseases. However, the exact role of Ser in OA remains unclear. Herein, we investigated the anti-arthritic effects as well as the potential mechanism of Ser on rat OA. Our results showed that Ser could markedly prevent the IL-1β-induced inflammatory reaction, cartilage degradation and cell apoptosis in rat chondrocytes. Meanwhile, the ASK1/P38/JNK and NFκB pathways were involved in the protective roles of Ser. Furthermore, intra-articular injection of Ser could significantly alleviate the surgery induced cartilage damage in rat OA model. In conclusion, our work provided insights into the therapeutic potential of Ser in OA, indicating that Ser might serve as a new avenue in OA treatment.
骨关节炎（OA）是一种常见的退行性关节疾病。其发展与软骨细胞中的炎症反应和细胞凋亡高度相关。凋亡信号调节激酶-1（ASK1）抑制剂塞洛西布（Ser）在多种疾病中已显示出多种治疗作用。然而，Ser在OA中的确切作用仍不清楚。在此，我们研究了Ser对大鼠OA的抗关节炎作用及其潜在机制。我们的结果表明，Ser可以显著预防白细胞介素-1β诱导的大鼠软骨细胞炎症反应、软骨降解和细胞凋亡。同时，ASK1/P38/JNK和NFκB信号通路参与了Ser的保护作用。此外，关节内注射Ser可以显著减轻大鼠OA模型中手术诱导的软骨损伤。总之，我们的工作为Ser在OA中的治疗潜力提供了见解，表明Ser可能成为OA治疗的新途径。
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