未成熟血小板分数（IPF）在脓毒症患者中的作用：一项系统综述。
Role of immature platelet fraction (IPF) in sepsis patients: A systematic review.
作者信息
Tauseef Abubakar, Zafar Maryam, Arshad Wafa, Thirumalareddy Joseph, Sood Akshat, Farooque Umar, Nair Sunil, Mirza Mohsin
机构信息
Internal Medicine Department, Creighton University Hospital Program, Omaha, Nebraska, USA.
Internal Medicine Department, Dow University of Health Sciences, Karachi, Pakistan.
出版信息
J Family Med Prim Care. 2021 Jun;10(6):2148-2152. doi: 10.4103/jfmpc.jfmpc_2293_20. Epub 2021 Jul 2.
Sepsis is extremely common amongst critically ill patients and requires early diagnosis. Hence, identifying a biomarker that could acknowledge sepsis at its prior stage is of vital significance. Immature platelets are a percentage of circulating platelets that contain RNA and is a newer parameter that is measured using automated hematology analyzers in diagnosing sepsis. This review article discusses 10 articles that reveal the role of immature platelet fraction in predicting the onset of sepsis and its relationship with mortality in sepsis. Literature search was done using PubMed, Scopus and Google Scholar and words like platelet indices and immature platelet fraction were typed in the search bar. The aim of this review article is to present a precise form of data that talk about immature platelet fraction (IPF) and its association with the severity and mortality of sepsis. Five out of 10 articles suggest that immature platelet fraction can predict the onset of sepsis and eight out of 10 articles suggest that increased IPF values are associated with high mortality.
脓毒症在重症患者中极为常见，需要早期诊断。因此，识别一种能够在脓毒症早期阶段予以确认的生物标志物至关重要。未成熟血小板是循环血小板中的一部分，含有RNA，是在诊断脓毒症时使用自动血液分析仪测量的一个较新参数。这篇综述文章讨论了10篇揭示未成熟血小板分数在预测脓毒症发作中的作用及其与脓毒症死亡率关系的文章。使用PubMed、Scopus和谷歌学术进行文献检索，并在搜索栏中输入血小板指数和未成熟血小板分数等词汇。这篇综述文章的目的是呈现关于未成熟血小板分数（IPF）及其与脓毒症严重程度和死亡率关联的精确数据形式。10篇文章中有5篇表明未成熟血小板分数可以预测脓毒症的发作，10篇文章中有8篇表明IPF值升高与高死亡率相关。
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