Theodoridis Dimitrios, Tsifi Angeliki, Magiorkinis Emmanouil, Ioannis Riris, Ioannis Vatistas, Moustaferi Evgenia, Christos Kanakaris, Ekaterini Tsiligianni, Ioannidis Anastasios, Chronopoulos Efstathios, Chatzipanagiotou Stylianos
Hematology Laboratory, Konstantopoulio General Hospital, Nea Ionia - Greece.
Ιntensive Care Unit, General Hospital of Athens EVANGELISMOS, Athens - Greece.
J Circ Biomark. 2025 Aug 14;14:21-29. doi: 10.33393/jcb.2025.3486. eCollection 2025 Jan-Dec.
Sepsis is a life-threatening condition and a major cause of hospital mortality worldwide. This study investigated the diagnostic utility of monocyte mean volume (MONO MEAN-V), monocyte distribution width (MDW), monocyte mean conductivity (MONO MEAN-C), and monocyte standard deviation conductivity (MONO Sd-C) for sepsis, compared to conventional markers.
A prospective cohort study was conducted in two centers, enrolling adult patients classified into three groups: sepsis, septic shock, and febrile. Blood was drawn from septic patients on days 1, 3, and 5 of admission. MDW and other inflammatory parameters were measured in all patients.
Patients with sepsis or septic shock exhibited significantly elevated MONO MEAN-V, MDW, and MONO MEAN-C and lower MONO Sd-C compared to febrile patients. Among the biomarkers evaluated, MDW emerged as a reliable predictor of sepsis. A cut-off MDW value of 25.1 on day 1 demonstrated optimal diagnostic performance, with an area under the ROC curve of 0.84 (95% CI: 0.77-0.91), sensitivity of 75%, and specificity of 91.2%.
MDW appears to be a cost-effective, rapid marker for sepsis detection, performing at least as effectively as existing biomarkers. Our findings corroborate other published studies, highlighting MDW's potential to enhance early sepsis recognition.
脓毒症是一种危及生命的病症，也是全球医院死亡率的主要原因。本研究调查了单核细胞平均体积（MONO MEAN-V）、单核细胞分布宽度（MDW）、单核细胞平均电导率（MONO MEAN-C）和单核细胞标准差电导率（MONO Sd-C）与传统标志物相比在脓毒症诊断中的效用。
在两个中心进行了一项前瞻性队列研究，纳入分为三组的成年患者：脓毒症组、感染性休克组和发热组。在入院第1天、第3天和第5天从脓毒症患者中采集血液。对所有患者测量MDW和其他炎症参数。
与发热患者相比，脓毒症或感染性休克患者的MONO MEAN-V、MDW和MONO MEAN-C显著升高，而MONO Sd-C较低。在评估的生物标志物中，MDW成为脓毒症的可靠预测指标。第1天MDW截断值为25.1时显示出最佳诊断性能，ROC曲线下面积为0.84（95%CI：0.77-0.91），敏感性为7５%，特异性为91.2%。
MDW似乎是一种经济高效、快速的脓毒症检测标志物，其表现至少与现有生物标志物一样有效。我们的研究结果证实了其他已发表的研究，突出了MDW在增强脓毒症早期识别方面的潜力。
