中风啮齿动物模型中的行为测试。
Behavioral tests in rodent models of stroke.
作者信息
Ruan Jingsong, Yao Yao
机构信息
Department of Pharmaceutical and Biomedical Sciences, University of Georgia, 240 W Green Street, Athens, GA, USA.
出版信息
Brain Hemorrhages. 2020 Dec;1(4):171-184. doi: 10.1016/j.hest.2020.09.001. Epub 2020 Sep 12.
Abstract
Rodents are the most widely used experimental animals in stroke research due to their similar vascular anatomy, high reproductive rates, and availability of transgenic models. However, the difficulties in assessing higher brain functions, such as cognition and memory, in rodents decrease the translational potential of these studies. In this review, we summarize commonly used motor/sensorimotor and cognition tests in rodent models of stroke. Specifically, we first briefly introduce the objective and procedure of each behavioral test. Next, we summarize the application of each test in both ischemic stroke and hemorrhagic stroke. Last, the advantages and disadvantages of these tests in assessing stroke outcome are discussed. This review summarizes commonly used behavioral tests in stroke studies and compares their applications in different stroke types.
摘要
由于啮齿动物具有相似的血管解剖结构、高繁殖率以及转基因模型的可用性，它们是中风研究中使用最广泛的实验动物。然而，在啮齿动物中评估诸如认知和记忆等高级脑功能存在困难，这降低了这些研究的转化潜力。在本综述中，我们总结了啮齿动物中风模型中常用的运动/感觉运动和认知测试。具体而言，我们首先简要介绍每个行为测试的目的和程序。接下来，我们总结每个测试在缺血性中风和出血性中风中的应用。最后，讨论这些测试在评估中风结果方面的优缺点。本综述总结了中风研究中常用的行为测试，并比较了它们在不同中风类型中的应用。
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