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癫痫外科学的进展。

Advances in Epilepsy Surgery.

机构信息

Deptartment of Neurology, Mayo Clinic & Nemours Children's Health System, Jacksonville, Florida.

Deptartment of Neurosurgery, University of Florida, Jacksonville, Florida.

出版信息

Pediatr Neurol. 2021 Sep;122:89-97. doi: 10.1016/j.pediatrneurol.2021.06.004. Epub 2021 Jun 18.

Abstract

BACKGROUND

A large number of patients have epilepsy that is intractable and adversely affects a child's lifelong experience with addition societal burden that is disabling and expensive. The last two decades have seen a major explosion of new antiseizure medication options. Despite these advances, children with epilepsy continue to have intractable seizures. An option that has been long available but little used is epilepsy surgery to control intractable epilepsy.

METHODS

This article is a review of the literature as well as published opinions.

RESULTS

Epilepsy surgery in pediatrics is an underused modality to effectively treat children with epilepsy. Adverse effects of medication should be weighed against risks of surgery as well as risks of nonefficacy.

CONCLUSIONS

We discuss an approach to selecting the appropriate pediatric patient for consideration, a detailed evaluation including necessary evaluation, and the creation of an algorithm to approach patients with both generalized and focal epilepsy. We then discuss surgical options available including outcome data. New modalities are also addressed including high-frequency ultrasound and co-registration techniques including magnetic resonance imaging-guided laser therapy.

摘要

背景

大量癫痫患者的癫痫发作难以控制,这对儿童的一生都会产生不利影响,增加了残疾和昂贵的社会负担。过去二十年中,新的抗癫痫药物选择出现了大幅增加。尽管取得了这些进展,但患有癫痫的儿童仍持续存在癫痫发作难以控制的情况。一种长期存在但使用较少的选择是癫痫手术来控制难治性癫痫。

方法

本文综述了文献和已发表的观点。

结果

儿童癫痫手术是一种未被充分利用的有效治疗癫痫儿童的方法。药物的不良反应应与手术风险以及无效风险相权衡。

结论

我们讨论了选择适当的儿科患者进行考虑的方法,包括必要评估的详细评估,并创建了一种算法来治疗全身性和局灶性癫痫患者。然后,我们讨论了可用的手术选择,包括结果数据。还讨论了新的方法,包括高频超声和包括磁共振成像引导激光治疗在内的配准技术。

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