探讨血清瘦素与肌少症性肥胖之间的关联。
Examining the Association Between Serum Leptin and Sarcopenic Obesity.
作者信息
Yang Zhe-Yu, Chen Wei-Liang
机构信息
Department of General Medicine, Tri-Service General Hospital; and School of Medicine, National Defense Medical Center, Taipei, Taiwan, Republic of China.
Division of Family Medicine, Department of Family and Community Medicine, Tri-Service General Hospital; and School of Medicine, National Defense Medical Center, Taipei, Taiwan, Republic of China.
出版信息
J Inflamm Res. 2021 Jul 22;14:3481-3487. doi: 10.2147/JIR.S320445. eCollection 2021.
OBJECTIVE
Sarcopenic obesity is an emerging geriatric syndrome among elderly individuals. Studies revealed a complicated pathogenesis between sarcopenia and obesity. Leptin, a proinflammatory adipokine, has been implicated in the mechanism of sarcopenic obesity. This study investigated the relationship between serum leptin level and sarcopenic obesity.
METHODS
The study included 4063 participants aged 60 years and older from the NHANES III database. Sarcopenia was defined as a skeletal muscle index (SMI) less than one standard deviation below the young adult value. Obesity was defined as a body mass index (BMIF) over 30 kg/m. Multivariate regression analysis was performed to examine the association between serum leptin level and sarcopenic obesity.
RESULTS
In adjusted models, serum leptin level was positively correlated with BMI (β: 1.33, p value < 0.001) and negatively correlated with SMI (β: -0.091, p value = 0.001). A significant association between serum leptin level and sarcopenic obesity was found in multivariate analysis (β: 4.011, p value=0.014).
CONCLUSION
Our study demonstrated that serum leptin level was related to an increased risk of sarcopenic obesity. This epidemiologic finding suggests that leptin may play a role in sarcopenic obesity.
目的
肌肉减少性肥胖是老年人群中一种新出现的老年综合征。研究揭示了肌肉减少症和肥胖症之间复杂的发病机制。瘦素是一种促炎脂肪因子，与肌肉减少性肥胖的机制有关。本研究调查了血清瘦素水平与肌肉减少性肥胖之间的关系。
方法
该研究纳入了来自美国国家健康与营养检查调查（NHANES）III数据库的4063名60岁及以上的参与者。肌肉减少症定义为骨骼肌指数（SMI）低于年轻成年人正常值一个标准差以下。肥胖症定义为体重指数（BMI）超过30kg/m²。进行多变量回归分析以检验血清瘦素水平与肌肉减少性肥胖之间的关联。
结果
在调整模型中，血清瘦素水平与BMI呈正相关（β：1.33，p值<0.001），与SMI呈负相关（β：-0.091，p值=0.001）。多变量分析发现血清瘦素水平与肌肉减少性肥胖之间存在显著关联（β：4.011，p值=0.014）。
结论
我们的研究表明血清瘦素水平与肌肉减少性肥胖风险增加有关。这一流行病学发现表明瘦素可能在肌肉减少性肥胖中起作用。
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